Madecassoside for Eczema (Atopic Dermatitis)

A purified compound from the cica (centella) plant, laser-focused on calming inflammation and speeding up how fast skin heals.

Why it works for Eczema (Atopic Dermatitis)

Calms inflammation and helps damaged skin repair. This is one purified compound from centella, and it has the strongest individual proof for soothing and healing a damaged barrier. It slows the breakdown of your skin's own hyaluronic acid and supports repair. It is used as a targeted add-in in CICA moisturizers for everyday eczema care.

How Madecassoside works

Purified triterpene from Centella; reduces inflammatory cytokines and accelerates re-epithelialization.

Evidence

4 citations from our ingredient database. Full citation list on the Madecassoside ingredient page.

journal2026

Liu L et al., Madecassoside Attenuated UVB Irradiation-Induced Skin Ferroptosis by Targeting POR, Phytomedicine 2026

review2023

Bandopadhyay S et al., Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review, Journal of Cellular and Molecular Medicine 2023;27(5):593-608 — comprehensive review of wound-healing, anti-inflammatory and regenerative activity

systematic review2021

Park KS, Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms, Evidence-Based Complementary and Alternative Medicine 2021;2021:5462633 — KR-authored review of triterpenes including madecassoside

journal2008

Haftek M et al., Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin, Experimental Dermatology 2008;17(11):946-52 — 6-month topical madecassoside + ascorbic acid produced measurable photoaging improvement

Products with Madecassoside in our catalog

These are the catalog products that list Madecassoside as a tracked ingredient.

Skin1004

Madagascar Centella Ampoule

$24 · Serum

La Roche-Posay

Hyalu B5 Pure Hyaluronic Acid Serum

$45 · Serum

Purito

Centella Unscented Serum

$20 · Serum

Torriden

Dive-In Low Molecular Hyaluronic Acid Serum

$20 · Serum

La Roche-Posay

Cicaplast Baume B5

$17 · Treatment

Dr. Jart+

Cicapair Tiger Grass Color Correcting Treatment SPF 30

$52 · SPF

Full Madecassoside guide →Eczema (Atopic Dermatitis) overview →