Conditions Melasma Glutathione
Gt
Moderate evidence

Glutathione for Melasma

A "master antioxidant" your body already makes. In skincare it gently lightens overall tone and helps fade pigmentation when used consistently over months.

Why it works for Melasma

Nudges your skin to make a lighter type of pigment instead of a darker one, and mops up some pigment-triggering damage. The topical evidence is modest and slow. The pill and IV versions are heavily marketed but the studies behind them are weak. Treat it as an add-on, not your main treatment.

How Glutathione works

Tripeptide antioxidant (γ-glutamyl-cysteinyl-glycine) that scavenges free radicals and shifts melanogenesis from dark eumelanin toward lighter pheomelanin by inhibiting tyrosinase.