Conditions Perioral dermatitis Azelaic Acid
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Moderate evidence

Azelaic Acid for Perioral dermatitis

Calms redness, fades acne marks, and clears bumps, all without aggravating sensitive skin. Pregnancy-safe.

Why it works for Perioral dermatitis

Calms the rash and clears the bumps. It quiets inflammation and keeps the microbes in the pores in check, and it does this without stripping your skin barrier. In a small study of 10 people, a 20 percent cream cleared the rash in 4 to 8 weeks (about 5.4 weeks on average), and the Searle 2021 review lists it as a workable option. Using it for this rash is off-label. It is approved for acne, rosacea, and dark patches.

How Azelaic Acid works

Dicarboxylic acid that inhibits tyrosinase and is antimicrobial against C. acnes.