Moderate evidence

Madecassoside for Rosacea

A purified compound from the cica (centella) plant, laser-focused on calming inflammation and speeding up how fast skin heals.

Why it works for Rosacea

Soothes irritated skin and helps it heal. It is the single most-studied compound pulled from centella for calming inflammation and repairing skin. A useful add-on to the gentle routine that rosacea guidelines recommend for every type of rosacea.

How Madecassoside works

Purified triterpene from Centella; reduces inflammatory cytokines and accelerates re-epithelialization.

Evidence

4 citations from our ingredient database. Full citation list on the Madecassoside ingredient page.

journal2026

Liu L et al., Madecassoside Attenuated UVB Irradiation-Induced Skin Ferroptosis by Targeting POR, Phytomedicine 2026

review2023

Bandopadhyay S et al., Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review, Journal of Cellular and Molecular Medicine 2023;27(5):593-608 — comprehensive review of wound-healing, anti-inflammatory and regenerative activity

systematic review2021

Park KS, Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms, Evidence-Based Complementary and Alternative Medicine 2021;2021:5462633 — KR-authored review of triterpenes including madecassoside

journal2008

Haftek M et al., Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin, Experimental Dermatology 2008;17(11):946-52 — 6-month topical madecassoside + ascorbic acid produced measurable photoaging improvement

Products with Madecassoside in our catalog

These are the catalog products that list Madecassoside as a tracked ingredient.

Skin1004

Madagascar Centella Ampoule

$24 · Serum

La Roche-Posay

Hyalu B5 Pure Hyaluronic Acid Serum

$45 · Serum

Purito

Centella Unscented Serum

$20 · Serum

Torriden

Dive-In Low Molecular Hyaluronic Acid Serum

$20 · Serum

La Roche-Posay

Cicaplast Baume B5

$17 · Treatment

Dr. Jart+

Cicapair Tiger Grass Color Correcting Treatment SPF 30

$52 · SPF

Full Madecassoside guide →Rosacea overview →