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Ingredients Anti-inflammatory Calendula
72Cd
Tier · Moderate evidence
Anti-inflammatory

Calendula

INCI: Calendula Officinalis Flower Extract · Also called: Marigold, Calendula Officinalis

A botanical with real clinical wins for irritated, post-procedure, or recovering skin, with randomized-trial support behind its soothing reputation. Gentle enough for delicate, easily reactive skin and dry, sensitive patches.

For your skin

A botanical with real clinical wins for irritated, post-procedure, or recovering skin, with randomized-trial support behind its soothing reputation. Gentle enough for delicate, easily reactive skin and dry, sensitive patches.

Want the science? Keep reading ↓

Mechanism of action

Marigold flower extract rich in triterpenoids (faradiol esters) and flavonoids that accelerate fibroblast migration, granulation tissue formation, and re-epithelialization in clinical wound trials.

Why we tier this moderate

6 cited papers across 4 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

3
International
1
European Union
1
United States
1
France

Cited research

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Deligiannidou GE et al. (Greece), An Update of Phytotherapeutic Advances of Marigold (Calendula officinalis L.) in Wound Healing, Plants (Basel) 2025 — peer-reviewed review of 2020-2025 experimental and clinical evidence on Calendula formulations for skin regeneration: healing rate, cell proliferation, inflammatory modulation

2025Meta-analysis (positive)PMID:41304647View source ↗
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Effect of oral Calendula officinalis on second-degree burn wound healing (Iran), Scars Burns and Healing 2023

2023Positive (efficacy)PMID:36632430View source ↗
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Siddiquee S et al., Efficacy of topical Calendula officinalis on prevalence of radiation-induced dermatitis: A randomised controlled trial, Australasian Journal of Dermatology 2021;62(1):e35-e40 — topical calendula reduced radiation-induced dermatitis

2021Positive (efficacy)PMID:32965030View source ↗
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Givol O et al., A systematic review of Calendula officinalis extract for wound healing, Wound Repair and Regeneration 2019

2019Meta-analysis (positive)PMID:31145533View source ↗
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Jahdi F et al. (Iran), The impact of calendula ointment on cesarean wound healing: A randomized controlled clinical trial, Journal of Family Medicine and Primary Care 2018;7(5):893-897

2018Positive (efficacy)PMID:30598929View source ↗
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Pommier P et al., Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer, Journal of Clinical Oncology 2004;22(8):1447-1453 — topical calendula significantly reduced acute radiation dermatitis

2004Positive (efficacy)PMID:15084618View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.