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94Ho
Tier · Moderate evidence
Anti-inflammatory · Anti-acne · Hydrating

Honey

INCI: Mel · Also called: Mel, Honey, Manuka Honey

An ancient humectant and antimicrobial ingredient with a long research track record. Its sugar matrix and flavonoids help draw in moisture and support skin comfort; formulas pairing honey with beeswax and olive oil have shown improvement in dry, irritation-prone skin in controlled trials.

For your skin

An ancient humectant and antimicrobial ingredient with a long research track record. Its sugar matrix and flavonoids help draw in moisture and support skin comfort; formulas pairing honey with beeswax and olive oil have shown improvement in dry, irritation-prone skin in controlled trials.

Want the science? Keep reading ↓

Mechanism of action

Hyperosmotic sugar matrix that draws fluid from wounds, generates low-level hydrogen peroxide via glucose oxidase, and (in Manuka grades) delivers methylglyoxal. Collectively bactericidal against C. acnes and S. aureus while supplying flavonoids that suppress inflammatory cytokines and accelerate re-epithelialisation.

Why we tier this moderate

5 cited papers across 1 country. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

5
International

Cited research

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Semprini A, Braithwaite I, Corin A, et al. Randomised controlled trial of topical kanuka honey for the treatment of acne. BMJ Open. 2016 Feb 1;6(2):e009448. — RCT: kanuka honey + antibacterial soap was NOT significantly more effective than antibacterial soap alone for acne; primary endpoint not met.

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Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;(3):CD005083.

2015Meta-analysis (mixed)PMID:25742878View source ↗
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Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011;1(2):154-160.

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Wijesinghe M, Weatherall M, Perrin K, Beasley R. Honey in the treatment of burns: a systematic review and meta-analysis of its efficacy. N Z Med J. 2009;122(1295):47-60.

2009Meta-analysis (positive)PMID:19648986View source ↗
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Ingle R, Levin J, Polinder K. Wound healing with honey--a randomised controlled trial. South African Medical Journal. 2006 Sep;96(9):831-835. — RCT comparing honey vs IntraSite Gel for wound healing; no significant difference in healing times between groups, though honey was safe, well-tolerated, and dramatically cheaper.

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.