94Ho
Tier · Moderate evidence
Anti-inflammatory · Anti-acne · Hydrating

Honey

INCI: Mel · Also called: Mel, Honey, Manuka Honey

An ancient antimicrobial that has graduated into modern wound clinics. Cochrane and meta-analytic evidence shows it heals partial-thickness burns ~4-5 days faster than conventional dressings; smaller dermatology trials show it calms atopic dermatitis flares without irritation.

For your skin

An ancient antimicrobial that has graduated into modern wound clinics. Cochrane and meta-analytic evidence shows it heals partial-thickness burns ~4-5 days faster than conventional dressings; smaller dermatology trials show it calms atopic dermatitis flares without irritation.

Want the science? Keep reading ↓

Mechanism of action

Hyperosmotic sugar matrix that draws fluid from wounds, generates low-level hydrogen peroxide via glucose oxidase, and (in Manuka grades) delivers methylglyoxal — collectively bactericidal against C. acnes and S. aureus while supplying flavonoids that suppress inflammatory cytokines and accelerate re-epithelialisation.

Why we tier this moderate

3 cited papers across 1 country. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

3
International

Cited research

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Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;(3):CD005083.

2015Meta-analysis — mixedPMID:25742878View source ↗
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Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011;1(2):154-160.

2011Mechanism onlyPMID:23569748View source ↗
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Wijesinghe M, Weatherall M, Perrin K, Beasley R. Honey in the treatment of burns: a systematic review and meta-analysis of its efficacy. N Z Med J. 2009;122(1295):47-60.

2009Meta-analysis — positivePMID:19648986View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.