Ingredients Anti-aging Hydrolyzed Collagen
78Hc
Tier · Moderate evidence
Anti-aging · Hydrating

Hydrolyzed Collagen

INCI: Hydrolyzed Collagen · Also called: Collagen Peptides, Marine Collagen, Fish Collagen

The protein your skin loses with age, broken down small enough to absorb. Multiple meta-analyses of RCTs show measurable wins in wrinkles, elasticity, and hydration after ~12 weeks. Most evidence is oral, but topical helps surface hydration too.

For your skin

The protein your skin loses with age, broken down small enough to absorb. Multiple meta-analyses of RCTs show measurable wins in wrinkles, elasticity, and hydration after ~12 weeks. Most evidence is oral, but topical helps surface hydration too.

Want the science? Keep reading ↓

Mechanism of action

Enzymatically cleaved collagen yielding low-MW di- and tri-peptides (Pro-Hyp, Hyp-Gly) that, when ingested, reach dermal fibroblasts and signal upregulated procollagen and hyaluronic acid synthesis; topically acts as a film-forming humectant.

Why we tier this moderate

3 cited papers across 2 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

2
International
1
Japan

Cited research

🌐

Pu SY et al., Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis, Nutrients 2023;15(9):2080 — 26 RCTs / 1,721 patients: hydrolyzed collagen significantly improved skin hydration and elasticity vs placebo across multiple collagen sources

2023Meta-analysis — positivePMID:37432180View source ↗
🌐

de Miranda RB, Weimer P, Rossi RC, Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis, International Journal of Dermatology 2021 — 19 RCTs / 1,125 participants: 90-day oral hydrolyzed collagen significantly reduced wrinkles and improved skin elasticity and hydration vs placebo

2021Meta-analysis — positivePMID:33742704View source ↗
🇯🇵

Evans M et al., A randomized triple-blind placebo-controlled parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity, Journal of Cosmetic Dermatology 2021;20(3):825-834 — 12-week RCT: ~35% reduction in wrinkle scores and improved elasticity vs placebo

2021Positive — efficacyPMID:32799362View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.