Ingredients Barrier repair Lanolin
92Ln
Tier · Moderate evidence
Barrier repair · Hydrating

Lanolin

INCI: Lanolin · Also called: Wool Wax, Wool Grease, Anhydrous Lanolin

Sheep-derived wax esters that mirror the molecules in your own skin lipids. Heals cracked nipples, dry hands, and damaged lips with multiple positive RCTs behind it. Note: classic but real allergen, so patch-test if you have a wool/Balsam-of-Peru history.

For your skin

Sheep-derived wax esters that mirror the molecules in your own skin lipids. Heals cracked nipples, dry hands, and damaged lips with multiple positive RCTs behind it. Note: classic but real allergen, so patch-test if you have a wool/Balsam-of-Peru history.

Want the science? Keep reading ↓

Mechanism of action

Complex wax-ester mixture from sheep sebaceous secretions whose chain-length distribution closely matches human stratum corneum lipids. Forms a semi-occlusive layer that holds twice its weight in water and integrates into the intercellular lipid lamellae rather than sitting on the surface like petrolatum.

Why we tier this moderate

3 cited papers across 2 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

2
International
1
United States

Cited research

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CIR Expert Panel. Amended Safety Assessment of Lanolin and Lanolin-Derived Ingredients as Used in Cosmetics. Cosmetic Ingredient Review Final Report. (Original 1980; reaffirmed 2005; updated 2024).

2024Safety assessmentCIR-Lanolin-2024View source ↗
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Peric O, Pavicic Bosnjak A, Mabic M, Tomic V. Comparison of Lanolin and Human Milk Treatment of Painful and Damaged Nipples: A Randomized Control Trial. J Hum Lact. 2023;39(2):310-319.

2023Positive — efficacyPMID:36401521View source ↗
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Vieira F, Mota DDCF, Castral TC, Guimaraes JV, Salge AKM, Bachion MM. Effects of Anhydrous Lanolin versus Breast Milk Combined with a Breast Shell for the Treatment of Nipple Trauma and Pain During Breastfeeding: A Randomized Clinical Trial. J Midwifery Womens Health. 2017;62(5):572-579.

2017Positive — efficacyPMID:28887855View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.