Ingredients Brightening Licorice Root
51Lc
Tier · Moderate evidence
Brightening · Anti-inflammatory

Licorice Root

INCI: Glycyrrhiza Glabra Root Extract · Also called: Glabridin, Licorice Extract

A gentle Asian-skincare brightener derived from licorice root. Fades dark spots and calms redness, and it's a pregnancy-safe alternative to stronger fade ingredients.

For your skin

A gentle Asian-skincare brightener derived from licorice root. Fades dark spots and calms redness, and it's a pregnancy-safe alternative to stronger fade ingredients.

Want the science? Keep reading ↓

Mechanism of action

Contains glabridin and liquiritin; inhibits tyrosinase and quenches inflammatory cytokines without affecting cell viability.

Why we tier this moderate

7 cited papers across 5 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

2
China
2
Japan
1
Korea
1
European Union
1
International

Cited research

🇨🇳

Liu Y et al., Glycyrrhiza glabra extract as a skin-whitening agent: Identification of active components and CRTC1/MITF pathway-inhibition mechanism, Journal of Ethnopharmacology 2025;349:119948 — identifies glabridin as the principal active and maps skin-whitening mechanism via CREB/CRTC1/MITF suppression

2025Mechanism onlyPMID:40350048View source ↗
🇨🇳

Wang JY et al., Preparation of compound liquorice microemulsion gel and its pharmacodynamics evaluation, Zhongguo Zhong Yao Za Zhi (China Journal of Chinese Materia Medica) 2020;45(21):5193-5199 — compound licorice (Glycyrrhiza) microemulsion gel significantly reduced ear swelling and inflammatory infiltration in chronic eczema mouse model

2020Positive — efficacyPMID:33350235View source ↗
🇰🇷

MFDS Notified Functional Cosmetic Active — Glabridin / Licorice (Glycyrrhiza Glabra) Root Extract (whitening). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List — glabridin (the active marker from licorice root) is a notified whitening active under the Korean Functional Cosmetics Codex

2020Regulatory approvalMFDS:Glabridin-WhiteningView source ↗
🇪🇺

Kowalska A, Kalinowska-Lis U (Poland), 18-beta-Glycyrrhetinic acid: its core biological properties and dermatological applications, International Journal of Cosmetic Science 2019;41(4):325-331 — licorice-derived 18-beta-glycyrrhetinic acid offers anti-inflammatory, antioxidant, and antimicrobial benefits for inflamed and photoaged skin

2019Mechanism onlyPMID:31166601View source ↗
🇯🇵

Seino H et al., Efficient Percutaneous Delivery of the Antimelanogenic Agent Glabridin Using Cationic Amphiphilic Chitosan Micelles, PLoS ONE 2016;11(10):e0164061 — chitosan-micelle-encapsulated glabridin penetrated skin ~4x more efficiently and inhibited melanogenesis

2016Mechanism onlyPMID:27695112View source ↗
🌐

Nerya O et al. (Israel), Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots, Journal of Agricultural and Food Chemistry 2003;51(5):1201-7 — glabrene and isoliquiritigenin from licorice produced dose-dependent inhibition of tyrosinase and melanin formation

2003Mechanism onlyPMID:12590456View source ↗
🇯🇵

Yokota T et al., The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation, Pigment Cell Research 1998;11(6):355-61 — glabridin inhibits both melanogenesis and inflammation via dual hydroxyl groups

1998Positive — efficacyPMID:9870547View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.