For your skin
Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.
Want the science? Keep reading ↓Mechanism of action
Signal peptide that stimulates fibroblasts to upregulate collagen I and III synthesis.
Why we tier this moderate
6 cited papers across 5 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.
Layering matrix
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Cited research
Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles
Aruan RR et al., Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet, Journal of Clinical and Aesthetic Dermatology 2023;16(2):37-43 — RCT of topical palmitoyl pentapeptide-4 (Matrixyl) for periorbital wrinkles
Imhof L, Leuthard D, Topical Over-the-Counter Antiaging Agents: An Update and Systematic Review, Dermatology 2021;237(2):217-229 — SR covering topical antiaging peptides
Lintner K, Gerstein F, Solish N, A serum containing vitamins C and E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos analysis, Journal of Cosmetic Dermatology 2020;19(12):3262-3269 — matrix-repair tripeptide serum: 8-9% roughness reduction, 9% redness reduction by Primos imaging
Choi YL et al., Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS), Biomolecules and Therapeutics (Seoul) 2014 — palmitoylation of KTTKS (Matrixyl) markedly improves dermal stability and skin permeation
Robinson LR et al., Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin, International Journal of Cosmetic Science 2005;27(3):155-60 — pal-KTTKS well tolerated and significantly reduced wrinkles/fine lines vs placebo
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.