For your skin
Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.
Want the science? Keep reading ↓Mechanism of action
Signal peptide that stimulates fibroblasts to upregulate collagen I and III synthesis.
Why we tier this moderate
7 cited papers across 4 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.
Layering matrix
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Cited research
Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles
Lintner K, Gerstein F, Solish N, A serum containing vitamins C and E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos analysis, Journal of Cosmetic Dermatology 2020;19(12):3262-3269 — matrix-repair tripeptide serum: 8-9% roughness reduction, 9% redness reduction by Primos imaging
MFDS Notified Functional Cosmetic Active — Palmitoyl Pentapeptide-4 / Matrixyl (anti-wrinkle, adjunct claim). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List. NOTE: this codex listing should be re-verified — official MFDS anti-wrinkle codex traditionally lists Retinol/Retinyl Palmitate/Polyethoxylated Retinamide/Adenosine; Matrixyl inclusion needs independent confirmation.
Bae JS et al., Topical application of palmitoyl-RGD reduces human facial wrinkle formation in Korean women, Archives of Dermatological Research 2017;309(8):665-671 — palmitoylated peptide reduced wrinkle formation via collagen activation and protection from degradation
Choi YL et al., Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS), Biomolecules and Therapeutics (Seoul) 2014 — palmitoylation of KTTKS (Matrixyl) markedly improves dermal stability and skin permeation
Byrne AJ et al., Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits, Journal of Cosmetic Dermatology 2010 — triple-peptide complex (Matrixyl-class) upregulated collagen IV and reduced wrinkles
Robinson LR et al., Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin, International Journal of Cosmetic Science 2005;27(3):155-60 — pal-KTTKS well tolerated and significantly reduced wrinkles/fine lines vs placebo
Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.