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Ingredients Sun protection Octocrylene
120Oy
Tier · Moderate evidence
Sun protection

Octocrylene

INCI: Octocrylene · Also called: Octocrilene, 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The quiet workhorse of chemical sunscreens: it adds UVB coverage but its real job is keeping avobenzone from falling apart in the sun, which is why the two are almost always paired. Well-established and effective. The one watch-point is that older, expired bottles can build up a benzophenone impurity, so do not hoard chemical sunscreens for years.

For your skin

The quiet workhorse of chemical sunscreens: it adds UVB coverage but its real job is keeping avobenzone from falling apart in the sun, which is why the two are almost always paired. Well-established and effective. The one watch-point is that older, expired bottles can build up a benzophenone impurity, so do not hoard chemical sunscreens for years.

Want the science? Keep reading ↓

Mechanism of action

Absorbs UVB and short UVA2 (280-320 nm) and, most importantly, photostabilises avobenzone: its structure dissipates absorbed energy and prevents avobenzone from degrading in sunlight, so it appears in most avobenzone-based Western sunscreens for that reason as much as its own filtering. FDA-approved OTC at up to 10%. A known caveat is that octocrylene can slowly degrade into benzophenone (a suspected carcinogen/allergen) as products age, so formulation freshness matters.

Why we tier this moderate

2 cited papers across 1 country. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

2
United States

Cited research

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Matta MK et al., Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial, JAMA 2020;323(3):256-267 — octocrylene systemic absorption measured; a widely used avobenzone photostabiliser

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FDA Proposed Rule, Sunscreen Drug Products for Over-the-Counter Human Use, 84 FR 6204 (26 February 2019) — octocrylene among the organic filters with GRASE status pending additional data

2019Safety assessment21CFR352View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.