Ingredients Antioxidant Resveratrol
54Rv
Tier · Moderate evidence
Antioxidant · Anti-aging · Brightening

Resveratrol

INCI: Resveratrol · Also called: trans-Resveratrol, 3,5,4'-Trihydroxystilbene

A grape-derived antioxidant that defends skin from daily oxidative damage and helps even out tone. Often paired with vitamins C and E in nighttime serums.

For your skin

A grape-derived antioxidant that defends skin from daily oxidative damage and helps even out tone. Often paired with vitamins C and E in nighttime serums.

Want the science? Keep reading ↓

Mechanism of action

Polyphenolic stilbene that scavenges reactive oxygen species, activates SIRT1, and inhibits tyrosinase and downstream melanogenic signaling.

Why we tier this moderate

5 cited papers across 3 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

2
International
2
United States
1
Korea

Cited research

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Shi Y, Shen C, Zhang W, Efficacy and safety of a topical skincare regimen containing CE Ferulic serum and resveratrol BE serum following ablative fractional CO2 laser treatment, Journal of the European Academy of Dermatology and Venereology 2024;38 Suppl 6:18-25 — split-face RCT, resveratrol-containing serum reduced erythema and accelerated wound healing post-laser

2024Positive — efficacyPMID:38828801View source ↗
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Boo YC, Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications, Antioxidants (Basel) 2019;8(9):332

2019Mechanism onlyPMID:31443469View source ↗
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Farris P, Zeichner J, Berson D, Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol, Journal of Drugs in Dermatology 2016;15(7):863-8

2016Positive — efficacyPMID:27391637View source ↗
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Choi DI et al., Ethanol Extract of Peanut Sprout Exhibits a Potent Anti-Inflammatory Activity, Annals of Dermatology 2015;27(2):142-151 — peanut sprout extract (high trans-resveratrol content, 176.75 µg/mL) suppressed COX-2 and NGF and inhibited NF-kB signaling in contact dermatitis model

2015Mechanism onlyPMID:25834352View source ↗
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Farris P, Yatskayer M, Chen N, Krol Y, Oresajo C, Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin E for treatment of mild to moderately photodamaged skin, Journal of Drugs in Dermatology 2014;13(12):1467-72 — 12-week clinical trial showed improvement in fine lines, firmness, elasticity, hyperpigmentation, radiance and ~19% dermal thickness gain

2014Positive — efficacyPMID:25607790View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.