Ingredients Antioxidant Tocotrienol
83Tn
Tier · Moderate evidence
Antioxidant · Anti-aging · Sun protection

Tocotrienol

INCI: Tocotrienols · Also called: Tocotrienol-Rich Fraction, TRF, Vitamin E (Tocotrienol)

Vitamin E's more potent cousin, better at chasing down free radicals and shielding skin from UV-driven aging. A systematic review concluded it protects against inflammation, UV damage, and pigmentation; pairs naturally with vitamin C.

For your skin

Vitamin E's more potent cousin, better at chasing down free radicals and shielding skin from UV-driven aging. A systematic review concluded it protects against inflammation, UV damage, and pigmentation; pairs naturally with vitamin C.

Want the science? Keep reading ↓

Mechanism of action

Unsaturated isoprenoid side-chain vitamin E homolog with 40-60x the lipid-peroxidation-quenching potency of alpha-tocopherol in some models; in fibroblasts upregulates COL1A1/COL3A1 genes and protects against UV-induced inflammation and melanogenesis.

Why we tier this moderate

2 cited papers across 1 country. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

2
International

Cited research

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Pang KL, Chin KY, Effects of tocotrienol on aging skin: A systematic review, Frontiers in Pharmacology 2022;13:1006198 — systematic review concludes tocotrienols protect skin from inflammation, UV radiation, and melanin accumulation

2022Meta-analysis — positivePMID:36299879View source ↗
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Makpol S et al., Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction, Archives of Medical Science 2011;7(5):889-895 — TRF pretreatment protected fibroblasts from H2O2-induced oxidative stress and upregulated COL I and COL III gene expression

2011Mechanism onlyPMID:22291837View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.