Shop Differin Acne Treatment Gel 0.1% Adapalene Retinoid (90 Day Supply, 45g Pump)
Treatment
Differin

Acne Treatment Gel 0.1% Adapalene Retinoid (90 Day Supply, 45g Pump)

~$24· 45g
AcneVisible pores

Tracked ingredients

Key actives from our research database. Click any to read the full evidence dossier.

Evidence behind the ingredients

Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

AdapaleneStrong evidence5 citations

A gentler prescription retinoid that focuses on clogged pores and acne. Better tolerated than tretinoin for most skin.

Stein Gold L et al., Moderate and Severe Inflammatory Acne Vulgaris Effectively Treated with Single-Agent Therapy by a New Fixed-Dose Combination Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel, American Journal of Clinical Dermatology 2016;17:293-303 — fixed-dose adapalene 0.3%/BPO 2.5% significantly superior to vehicle for moderate-severe inflammatory acne

2016Positive — efficacyPMID:26945741View source ↗

Effects of adapalene-benzoyl peroxide combination gel in treatment or maintenance therapy of moderate or severe acne vulgaris: a meta-analysis, Annals of Dermatology 2014;26(1):43-52 — A-BPO combination yields better clinical outcomes (success rate, satisfaction) vs vehicle gel

2014Meta-analysis — positivePMID:24648685View source ↗

Poulin Y et al., A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris, British Journal of Dermatology 2011 — adapalene-BPO maintenance delayed relapse by ~17 weeks vs vehicle

2011Positive — efficacyPMID:21457209View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Adapalene + glycolic acid can over-exfoliate. Alternate nights.

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