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Ingredients Anti-inflammatory Aloe Vera
47Av
Sourced from herb
Tier · Moderate evidence
Anti-inflammatory · Hydrating

Aloe Vera

INCI: Aloe Barbadensis Leaf Juice · Also called: Aloe

Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

For your skin

Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

Want the science? Keep reading ↓

Mechanism of action

Polysaccharide- and glycoprotein-rich plant gel that soothes irritation and supports wound healing.

Why we tier this moderate

7 cited papers across 3 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

4
International
2
United States
1
Taiwan

Layering matrix

Cited research

🇹🇼

Huang YN et al., Effects of Aloe vera on Burn Injuries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Burn Care & Research 2024;45(6):1536-1545 — topical aloe vera reduced burn wound-healing time

2024Meta-analysis (positive)PMID:38605441View source ↗
🌐

Tungkasamit T et al., Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial, European Journal of Oncology Nursing 2022;59:102164 — aloe vera reduced severity of moderate-to-severe radiation dermatitis

2022Positive (efficacy)PMID:35767935View source ↗
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Sharma S et al., Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review, Advances in Skin & Wound Care 2022;35(11):1-9 — topical aloe vera shortened time to healing for second-degree burns

2022Meta-analysis (positive)PMID:36264753View source ↗
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Hekmatpou D et al., The effect of aloe vera clinical trials on prevention and healing of skin wound: a systematic review, Iranian Journal of Medical Sciences 2019;44(1):1-9

2019Meta-analysis (positive)PMID:30666070View source ↗
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Burusapat C et al., Topical Aloe Vera Gel for Accelerated Wound Healing of Split-Thickness Skin Graft Donor Sites: A Double-Blind, Randomized, Controlled Trial and Systematic Review, Plastic and Reconstructive Surgery 2018;142(1):217-226 — aloe vera gel shortened donor-site reepithelialization to 11.5 vs 13.7 days

2018Positive (efficacy)PMID:29649056View source ↗
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Dat AD et al., Aloe vera for treating acute and chronic wounds, Cochrane Database of Systematic Reviews 2012;2012(2):CD008762 — Cochrane review; evidence for topical aloe on wound healing was limited/low-certainty

2012Meta-analysis (mixed)PMID:22336851View source ↗
🇺🇸

Surjushe A et al., Aloe vera: a short review, Indian Journal of Dermatology 2008;53(4):163-6 — concluded "controlled trials are needed to determine real efficacy"

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.