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Ingredients Anti-inflammatory Heartleaf
31He
Sourced from heartleaf
Tier · Moderate evidence
Anti-inflammatory · Anti-acne

Heartleaf

INCI: Houttuynia Cordata Extract · Also called: Eo Seong Cho, Fish Mint

A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.

For your skin

A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.

Want the science? Keep reading ↓

Mechanism of action

Quercetin-rich botanical with antimicrobial and anti-inflammatory effects useful in acne-prone skin.

Why we tier this moderate

8 cited papers across 4 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

4
International
2
Korea
1
China
1
Japan

Layering matrix

Cited research

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Song Z et al., Inhibition of LPS-Induced Skin Inflammatory Response and Barrier Damage via MAPK/NF-kB Signaling Pathway by Houttuynia cordata Thunb Fermentation Broth, Foods 2024

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Kwon N et al., Protective Effects of Fermented Houttuynia cordata Against UVA and H2O2-Induced Oxidative Stress in Human Skin Keratinocytes, Applied Biochemistry and Biotechnology 2023;195(5):3027-3046 — Korean-authored; fermented H. cordata showed antioxidant and anti-inflammatory protection against UVA/H2O2 stress

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Rafiq S et al., Pharmacological Effects of Houttuynia cordata Thunb (H. cordata): A Comprehensive Review, Pharmaceuticals (Basel) 2022

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Yang JH et al., Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: an 8-week, double-blinded, randomized, controlled trial, J Dermatolog Treat 2021;32(3):297-301 — DB RCT n=60; multi-herb combo — benefit not isolated to Houttuynia

2021Positive (efficacy)PMID:31424962View source ↗
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Wu Z et al., Houttuynia cordata Thunb: An Ethnopharmacological Review, Frontiers in Pharmacology 2021;12:714694 — anti-inflammatory, antibacterial, antiviral effects supporting topical applications

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Mapoung S et al., Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway, Plants 2021;10(12):2628 — hyperoside-enriched H. cordata protected fibroblasts from UVB-induced collagen breakdown

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Shingnaisui K et al., Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review, Journal of Ethnopharmacology 2018;220:35-43 — H. cordata extracts possess anti-inflammatory and antioxidant properties with no demonstrated toxicity

🇯🇵

Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice, Bioscience, Biotechnology, and Biochemistry 2016 — in-vitro mechanism; no human controlled trial for skin to date. (Published in a Japanese journal: BBB is the official journal of the Japan Society for Bioscience, Biotechnology, and Agrochemistry; J-Stage-indexed.)

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.