Ingredients Hydrating Hyaluronic Acid
13HA
Sourced from microbe + lab
Tier · Strong evidence
Hydrating

Hyaluronic Acid

INCI: Sodium Hyaluronate · Also called: HA, Hyaluronan

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

For your skin

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Want the science? Keep reading ↓

Mechanism of action

Polysaccharide humectant that binds up to 1000x its weight in water within the stratum corneum.

Why we tier this strong

6 cited papers across 4 countries. Multiple positive efficacy results plus regulatory backing. Clears our published bar (Strong = 15+ studies with multiple randomized controlled trials (RCTs), or a single large longitudinal cohort).

2
International
2
United States
1
Korea
1
France

Layering matrix

Read the research

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Cited research

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Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis — positivePMID:36200921View source ↗
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An JH et al., Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin, Annals of Dermatology 2019;31(3):263-271 — cross-linked HA microneedle patches improved wrinkles on Korean skin with minimal discomfort

2019Positive — efficacyPMID:33911590View source ↗
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Jegasothy SM et al., Efficacy of a New Topical Nano-hyaluronic Acid in Humans, Journal of Clinical and Aesthetic Dermatology 2014;7(3):27-29 — nano-HA produced up to 40% wrinkle-depth reduction, 96% hydration increase, and 55% elasticity improvement over 8 weeks

2014Positive — efficacyPMID:24688623View source ↗
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Papakonstantinou E et al., Hyaluronic acid: A key molecule in skin aging, Dermato-Endocrinology 2012;4(3):253-8 — mechanism review (not a clinical efficacy claim)

2012Mechanism onlyPMID:23467280View source ↗
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Pavicic T et al., Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment, Journal of Drugs in Dermatology 2011;10(9):990-1000 — low-MW HA significantly reduced wrinkle depth, all formulations improved hydration and elasticity

2011Positive — efficacyPMID:22052267View source ↗
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Pomarede N, [Hyaluronic acid], Annales de Dermatologie et de Vénéréologie 2008;135(1 Pt 2):1S35-8 — HA "a leader product in esthetic procedures for the treatment of wrinkles and volumes"; structure, metabolism, physiological function, injection technique review

2008Positive — efficacyPMID:18442661View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.