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Shop Differin Maximum Strength Acne Foaming Cleanser 10% Benzoyl Peroxide
Cleanser
Differin

Maximum Strength Acne Foaming Cleanser 10% Benzoyl Peroxide

~$11· 5 Fl Oz (Pack of 1)

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • Benzoyl PeroxideStrong evidenceFull dossier ↗

    Kills the bacteria that cause inflammatory acne. The first thing to reach for when you have red, painful pimples.

    Good for: Anti-acne

  • GlycerinModerate evidenceFull dossier ↗

    A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

    Good for: Hydrating

New to this? Patch test on your inner arm for 24 to 48 hours before applying to your face. If you have sensitive skin or rosacea, start 2 to 3 times per week and build up slowly.

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Benzoyl PeroxideStrong evidence7 citations

Kills the bacteria that cause inflammatory acne. The first thing to reach for when you have red, painful pimples.

Barbieri JS et al. Benzoyl Peroxide-Containing Products and Benzene: Where Are We Now After Recalls, and How Should We Move Forward? JAMA Dermatology. 2025;161(8). doi:10.1001/jamadermatol.2025.1694 — Viewpoint examining benzene formation risk in benzoyl peroxide products following product recalls; discusses monitoring and regulatory considerations for BPO safety.

2025Safety assessmentPMID:40531498View source ↗

Barbieri JS et al. The Role of Formulation in Benzene Formation in Benzoyl Peroxide Products. JAMA Dermatology. 2025;161(4). doi:10.1001/jamadermatol.2024.6443 — Quality improvement study examining how OTC benzoyl peroxide product formulation characteristics affect detected benzene concentration levels.

2025Safety assessmentPMID:39937513View source ↗

Huang CY et al., Comparative Efficacy of Pharmacological Treatments for Acne Vulgaris: A Network Meta-Analysis of 221 Randomized Controlled Trials, Annals of Family Medicine 2023;21(4):358-369 — BPO combinations among most effective topical regimens for acne

2023Meta-analysis (positive)PMID:37487721View source ↗
GlycerinModerate evidence6 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive (efficacy)PMID:35167133View source ↗

Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin

2021Positive (efficacy)PMID:31869257View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive (efficacy)PMID:28889318View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Vitamin Cmedium

    Benzoyl peroxide breaks down vitamin C, making both less effective. Use one in the morning and the other at night.

  • Retinolmedium

    Benzoyl peroxide can break down retinol. Use one in the morning and the other at night, or pick a stabilized formula made to combine them.

  • Tretinoinmedium

    Benzoyl peroxide breaks down tretinoin unless they're in a stabilized formula made to combine them. Use one in the morning and the other at night.

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Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.