Double Up Cream NAD+ NMN & TXA
What it's good for
Key actives from our research database. Click any to read the full evidence dossier.
The "longevity molecule" of cellular skincare. It supports NAD+ production, which early research links to cellular repair and skin barrier function. Human trial data on topical NMN is still thin -- think of it as a promising frontier ingredient rather than a proven active.
Good for: Anti-aging, Barrier repair
The ultimate "cell recharger." It boosts your skin's cellular energy to speed up repair and protect against aging at the DNA level. It's the new high-tech standard for longevity skincare.
Good for: Anti-aging, Barrier repair
Evidence behind the ingredients
Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
The "longevity molecule" of cellular skincare. It supports NAD+ production, which early research links to cellular repair and skin barrier function. Human trial data on topical NMN is still thin -- think of it as a promising frontier ingredient rather than a proven active.
Sun Z et al., Small extracellular vesicles loaded with NMN activate NAD+/SIRT3 signaling to delay skin aging, Stem Cell Research & Therapy 2025;16(1):339
Irie J et al., Effect of oral administration of nicotinamide mononucleotide on clinical parameters in healthy men, Endocrine Journal 2020;67(2):153-160 (KCI Indexed)
The ultimate "cell recharger." It boosts your skin's cellular energy to speed up repair and protect against aging at the DNA level. It's the new high-tech standard for longevity skincare.
Ministrini S, Liberale L, Erle HE, Percoco G, Tfayli A, Assi A, Kapitonov I, Greiner I, Camici GG, A Liposomal Formulation Enhances the Anti-Senescence Properties of Nicotinamide Adenine-Dinucleotide (NAD+) in Endothelial Cells and Keratinocytes, Current Issues in Molecular Biology 2025 — in-vitro: liposomal NAD+ reduced senescent cells in human keratinocytes and endothelial cells and increased skin penetration ~30% vs free NAD+ (cell-based mechanism)
Kang S, Park J, Cheng Z, Ye S, Jun SH, Kang NG, Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+) by Synergistic Inhibition of CD38 Expression, Cells 2024 — in-vitro: exogenous NAD+ on human fibroblasts protected against UV-induced and intrinsic aging via sirtuin/autophagy pathways; effect amplified by CD38 inhibition (cell-based mechanism)
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.
Similar comparisons
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