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Shop medicube AGE-R Glutathione Glow Capsule Cream
Moisturizer
medicube

AGE-R Glutathione Glow Capsule Cream

~$25.65· Standard Size

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • NiacinamideStrong evidenceFull dossier ↗

    A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

    Good for: Brightening, Barrier repair, Anti-inflammatory

  • CeramidesStrong evidenceFull dossier ↗

    Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

    Good for: Barrier repair

  • AdenosineModerate evidenceFull dossier ↗

    A Korean-approved anti-wrinkle ingredient that encourages collagen production for a smoother, firmer look.

    Good for: Anti-aging

  • GlycerinModerate evidenceFull dossier ↗

    A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

    Good for: Hydrating

  • GlutathioneModerate evidenceFull dossier ↗

    A "master antioxidant" your body already makes. In skincare it gently lightens overall tone and helps fade pigmentation when used consistently over months.

    Good for: Brightening, Antioxidant

  • DimethiconeStrong evidenceFull dossier ↗

    A silicone that sits on your skin as an invisible, non-greasy shield. Reduces water loss, protects against irritants (think soap, friction, incontinence), and is FDA-recognised as a skin protectant from 1-30%. The reason your favourite primer feels silky and your barrier cream actually works under makeup.

    Good for: Barrier repair, Hydrating

  • Alpha-Lipoic AcidModerate evidenceFull dossier ↗

    A "universal antioxidant" that protects both the oily and watery parts of your skin. It's unique because it can recycle your Vitamin C and E, making them last longer. It also prevents "sugar-sag" (glycation) and reduces fine lines.

    Good for: Antioxidant, Anti-aging

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

NiacinamideStrong evidence10 citations

A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278444View source ↗

Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026

2026Positive (efficacy)PMID:41240206View source ↗

Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025

2025Positive (efficacy)PMID:39171587View source ↗
CeramidesStrong evidence7 citations

Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control

2025Positive (efficacy)PMID:40408261View source ↗

Nugroho WT, Sawitri, Astindari, Utomo B, Listiawan MY, Ervianti E, Astari L. The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis. Indian J Dermatol. 2023;68(1):53-58. — Meta-analysis of 5 studies found ceramide-containing moisturisers produced significantly greater improvement in SCORAD compared with non-ceramide moisturisers in atopic dermatitis.

2023Meta-analysis (positive)PMID:37151263View source ↗

Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults

2022Positive (efficacy)PMID:35298858View source ↗
AdenosineModerate evidence6 citations

A Korean-approved anti-wrinkle ingredient that encourages collagen production for a smoother, firmer look.

Yang HJ et al., Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement, Journal of Cosmetic Dermatology 2019;18(3):936-943 — Korean clinical study (n=20): adenosine microneedle patches improved elasticity, hydration, dermal density, wrinkles

2019Positive (efficacy)PMID:30160014View source ↗

Kang G et al., Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration, International Journal of Cosmetic Science 2018;40(2):199-206 — Korean-authored; adenosine microneedle patches matched or exceeded adenosine cream for multiple endpoints

2018Positive (efficacy)PMID:29574973View source ↗

Kim MY et al., Effect of adenosine on melanogenesis in B16 cells and zebrafish, Annals of Dermatology 2014;26(2):209-13 — adenosine suppresses pigmentation via negative regulation of tyrosinase in cellular and zebrafish models

2014Mechanism onlyPMID:24882976View source ↗
+4 more ingredients
GlycerinModerate evidence6 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive (efficacy)PMID:35167133View source ↗

Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin

2021Positive (efficacy)PMID:31869257View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive (efficacy)PMID:28889318View source ↗
GlutathioneModerate evidence5 citations

A "master antioxidant" your body already makes. In skincare it gently lightens overall tone and helps fade pigmentation when used consistently over months.

Stanescu C et al., Glutathione in Skin Aging and Tissue Regeneration: A Systematic Review of Molecular Mechanisms, Redox Modulation, and Biomedical Implications, Molecules 2026

2026Meta-analysis (positive)PMID:41900080View source ↗

Sarkar R et al., Glutathione as a skin-lightening agent and in melasma: a systematic review, International Journal of Dermatology 2025

2025Meta-analysis (mixed)PMID:39444151View source ↗

Wahab S et al., Combination of topical and oral glutathione as a skin-whitening agent: a double-blind randomized controlled clinical trial, International Journal of Dermatology 2021;60(8):1013-1018 — 8-week RCT showed combination significantly lowered melanin and raised lightness vs placebo

2021Positive (efficacy)PMID:33871071View source ↗
DimethiconeStrong evidence5 citations

A silicone that sits on your skin as an invisible, non-greasy shield. Reduces water loss, protects against irritants (think soap, friction, incontinence), and is FDA-recognised as a skin protectant from 1-30%. The reason your favourite primer feels silky and your barrier cream actually works under makeup.

Beeckman D, Verhaeghe S, Defloor T, et al. A 3-in-1 perineal care washcloth impregnated with dimethicone 3% versus water and pH neutral soap to prevent and treat incontinence-associated dermatitis: a randomized, controlled clinical trial. J Wound Ostomy Continence Nurs. 2011;38(6):627-634.

2011Positive (efficacy)PMID:21952346View source ↗

Saary J, Qureshi R, Palda V, et al. A systematic review of contact dermatitis treatment and prevention. J Am Acad Dermatol. 2005;53(5):845-855. (Barrier creams containing dimethicone prevent irritant contact dermatitis.)

2005Meta-analysis (positive)PMID:16243136View source ↗

FDA OTC Final Monograph, 21 CFR Part 347 — Skin Protectant Drug Products for Over-the-Counter Human Use; dimethicone listed at section 347.10 as a Category I active ingredient at 1-30%.

2003Regulatory approval21CFR347.10View source ↗
Alpha-Lipoic AcidModerate evidence2 citations

A "universal antioxidant" that protects both the oily and watery parts of your skin. It's unique because it can recycle your Vitamin C and E, making them last longer. It also prevents "sugar-sag" (glycation) and reduces fine lines.

Lee WJ et al., Anti-Inflammatory and Antioxidative Effects of Alpha Lipoic Acid on Cultured Human Sebocytes, Annals of Dermatology 2019

2019Mechanism onlyPMID:33911546View source ↗

Beitner H, Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin, British Journal of Dermatology 2003;149(4):841-9

2003Positive (efficacy)PMID:14616378View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

Full ingredient list

Everything on the package label, not just the tracked actives above.

Drying alcohol freeSulfates freeParabens free
  • Contains fragrance: Fragrance, Limonene, CitralWorth knowing if you have sensitive or reactive skin.
  • Contains silicones: Vinyl Dimethicone, Dimethiconol, Phenyl TrimethiconeNo irritancy evidence. CIR rates this safe as used; some shoppers avoid it by preference.
+Show all 42 ingredients

Listed in the order printed on the package. By regulation, ingredients at 1% or higher are listed in descending order by concentration, so the first entry is the largest part of the formula.

  1. Water(Aqua)
  2. Glycerin
  3. 1,2-Hexanediol
  4. Polyglyceryl-10 Laurate
  5. Hydrogenated Lecithin
  6. Glutathione
  7. Butylene Glycol
  8. Chondrus Crispus Powder
  9. Agar
  10. Tromethamine
  11. Acrylates/​C10-30 Alkyl Acrylate Crosspolymer
  12. Gellan Gum
  13. Glycereth-26
  14. Glyceryl Acrylate/​Acrylic Acid Copolymer
  15. Methylpropanediol
  16. Vinyl Dimethicone
  17. Dimethiconol
  18. Niacinamide
  19. Betaine
  20. Sodium Polyacrylate
  21. C18-21 Alkane
  22. Polyglyceryl-10 Oleate
  23. Isononyl Isononanoate
  24. Isohexadecane
  25. Ammonium Acryloyldimethyltaurate/​VP Copolymer
  26. Phenyl Trimethicone
  27. Fragrance
  28. Limonene
  29. Citral
  30. Ethylhexylglycerin
  31. Xanthan Gum
  32. Adenosine
  33. Glucose
  34. Caprylic/​Capric Triglyceride
  35. Ceramide NP
  36. Palmitoyl Tripeptide-5
  37. Sorbitan Laurate
  38. Hydroxyethylcellulose
  39. Acetyl Dipeptide-1 Cetyl Ester
  40. Acetyl Hexapeptide-1
  41. Thioctic Acid
  42. Soluble Collagen

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