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Shop Naturium Multi-Peptide Moisturizer
Moisturizer
Naturium

Multi-Peptide Moisturizer

~$19.88· 1.7 oz
Fine lines & firmness

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • Matrixyl PeptidesModerate evidenceFull dossier ↗

    Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

    Good for: Anti-aging

  • Vitamin CStrong evidenceFull dossier ↗

    Brightens dull skin and helps fade dark spots. Also defends against everyday UV and pollution damage when worn under sunscreen.

    Good for: Brightening, Antioxidant

  • PanthenolModerate evidenceFull dossier ↗

    Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.

    Good for: Hydrating, Barrier repair

New to this? Patch test on your inner arm for 24 to 48 hours before applying to your face. If you have sensitive skin or rosacea, start 2 to 3 times per week and build up slowly.

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Matrixyl PeptidesModerate evidence6 citations

Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles

2024Positive (efficacy)PMID:38932444View source ↗

Aruan RR et al., Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet, Journal of Clinical and Aesthetic Dermatology 2023;16(2):37-43 — RCT of topical palmitoyl pentapeptide-4 (Matrixyl) for periorbital wrinkles

2023Positive (efficacy)PMID:36909866View source ↗

Imhof L, Leuthard D, Topical Over-the-Counter Antiaging Agents: An Update and Systematic Review, Dermatology 2021;237(2):217-229 — SR covering topical antiaging peptides

2021Meta-analysis (positive)PMID:32882685View source ↗
Vitamin CStrong evidence15 citations

Brightens dull skin and helps fade dark spots. Also defends against everyday UV and pollution damage when worn under sunscreen.

Krutmann J et al. PINGing Sunshine: A Review of the Evidence for Adding Non-Filtering Photoprotective Ingredients to Sunscreens. Photodermatol Photoimmunol Photomed. 2025;41(6). — Review of Photoprotective INGredients (PINGs); L-ascorbic acid (vitamin C) identified as a top-ranked PING demonstrating efficacy across multiple photodamage endpoints.

2025Meta-analysis (positive)PMID:41152208View source ↗

Pullar JM et al., The roles of vitamin C in skin health, Nutrients 2017;9(8):866 — concluded topical efficacy "poorly understood"; supports dietary vitamin C

2017Mechanism onlyPMID:28805671View source ↗

Lee JH et al., Effects of VitabridC12 on Skin Inflammation, Annals of Dermatology 2017

2017Mechanism onlyPMID:28966510View source ↗
PanthenolModerate evidence5 citations

Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.

Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline

2025Positive (efficacy)PMID:40613435View source ↗

Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD

2022Meta-analysis (positive)PMID:35887707View source ↗

Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser

2019Positive (efficacy)PMID:30897983View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

Full ingredient list

Everything on the package label, not just the tracked actives above.

Fragrance freeDrying alcohol freeSulfates freeParabens free
  • Contains silicones: DimethiconeNo irritancy evidence. CIR rates this safe as used; some shoppers avoid it by preference.
+Show all 48 ingredients

Listed in the order printed on the package. By regulation, ingredients at 1% or higher are listed in descending order by concentration, so the first entry is the largest part of the formula.

  1. Aqua
  2. Glycerin
  3. Dimethicone
  4. Simmondsia Chinensis (Jojoba) Seed Oil
  5. Squalane
  6. Glyceryl Stearate
  7. Cetyl Alcohol
  8. Niacinamide
  9. Stearyl Alcohol
  10. Palmitoyl Tripeptide-5
  11. Pantolactone
  12. Palmitoyl Tripeptide-1
  13. Palmitoyl Tetrapeptide-7
  14. Hydrolyzed Plukenetia Volubilis Seed Extract
  15. Dunaliella Salina Extract
  16. Sodium Hyaluronate
  17. 3-O-Ethyl Ascorbic Acid
  18. Panthenol
  19. Caryodendron Orinocense Seed Oil
  20. Honokiol
  21. Magnolol
  22. Palmitic Acid
  23. Sorbitan Oleate
  24. Aluminum Starch Octenylsuccinate
  25. Hydroxyacetophenone
  26. Stearic Acid
  27. Acrylamide/​Sodium Acryloyldimethyltaurate Copolymer
  28. Polyglyceryl-6 Laurate
  29. 1,2-Hexanediol
  30. Boron Nitride
  31. Caprylyl Glycol
  32. Polyglyceryl-10 Oleate
  33. Isohexadecane
  34. Butylene Glycol
  35. Chlorphenesin
  36. Acrylates/​C10-30 Alkyl Acrylate Crosspolymer
  37. Tocopheryl Acetate
  38. Polysorbate 80
  39. Sorbitan Palmitate
  40. Sodium Hydroxide
  41. Sodium Benzoate
  42. Carbomer
  43. Sodium Lactate
  44. Phenoxyethanol
  45. Polysorbate 20
  46. Citric Acid
  47. Ethylhexylglycerin
  48. Potassium Sorbate

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Benzoyl peroxide breaks down vitamin C, making both less effective. Use one in the morning and the other at night.

  • Vitamin C and retinol work best at different pH levels. Use vitamin C in the morning and retinol at night.

Similar comparisons

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Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.