Shop Sulwhasoo First Care Activating Serum
Essence
Sulwhasoo

First Care Activating Serum

~$105· 60ml / 2.02 fl oz
Fine lines & firmnessDrynessRadianceDark spots

Tracked ingredients

Key actives from our research database. Click any to read the full evidence dossier.

Evidence behind the ingredients

Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Panax GinsengStrong evidence5 citations

A staple in Hanbang (traditional Korean medicine) skincare. It's packed with antioxidants and ginsenosides that help firm the skin, boost circulation, and defend against environmental aging.

Jung SW et al., Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair, Annals of Dermatology 2025

2025Mechanism onlyPMID:39894668View source ↗

Kim H et al., The Beneficial Effect of Korean Red Ginseng Extract on Atopic Dermatitis Patients: An 8 Weeks Open, Noncomparative Clinical Study, Annals of Dermatology 2018

2018Positive — efficacyPMID:29853744View source ↗

Park HM et al., A single-center, randomized, double-blind, placebo-controlled study on the efficacy and safety of enzyme-treated red ginseng powder complex (BG11001) for antiwrinkle and proelasticity in individuals with healthy skin, Journal of Ginseng Research 2016

2016Positive — efficacyPMID:27616902View source ↗
HoneyModerate evidence3 citations

An ancient antimicrobial that has graduated into modern wound clinics. Cochrane and meta-analytic evidence shows it heals partial-thickness burns ~4-5 days faster than conventional dressings; smaller dermatology trials show it calms atopic dermatitis flares without irritation.

Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;(3):CD005083.

2015Meta-analysis — mixedPMID:25742878View source ↗

Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011;1(2):154-160.

2011Mechanism onlyPMID:23569748View source ↗

Wijesinghe M, Weatherall M, Perrin K, Beasley R. Honey in the treatment of burns: a systematic review and meta-analysis of its efficacy. N Z Med J. 2009;122(1295):47-60.

2009Meta-analysis — positivePMID:19648986View source ↗
MadecassosideModerate evidence6 citations

A purified compound from the cica (centella) plant, laser-focused on calming inflammation and speeding up how fast skin heals.

Liu L et al., Madecassoside Attenuated UVB Irradiation-Induced Skin Ferroptosis by Targeting POR, Phytomedicine 2026

2026Mechanism onlyPMID:41421280View source ↗

Bandopadhyay S et al., Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review, Journal of Cellular and Molecular Medicine 2023;27(5):593-608 — comprehensive review of wound-healing, anti-inflammatory and regenerative activity

2023Meta-analysis — positivePMID:36756687View source ↗

Park KS, Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms, Evidence-Based Complementary and Alternative Medicine 2021;2021:5462633 — KR-authored review of triterpenes including madecassoside

2021Meta-analysis — positivePMID:34845411View source ↗
+2 more ingredients
AdenosineModerate evidence7 citations

A Korean-approved anti-wrinkle ingredient that encourages collagen production for a smoother, firmer look.

Nguyen NH et al., Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278371View source ↗

MFDS Approved Functional Cosmetic Active — Adenosine (anti-wrinkle). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List

2020Regulatory approvalMFDS:Adenosine-AntiWrinkleView source ↗

Jang M et al., Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity, International Journal of Cosmetic Science 2020;42(3):302-309 — Korean comparison: HMW HA + adenosine outperformed LMW HA across wrinkle and elasticity parameters

2020Positive — efficacyPMID:32421218View source ↗
Vitamin CStrong evidence14 citations

Brightens dull skin and helps fade dark spots. Also defends against everyday UV and pollution damage when worn under sunscreen.

Pullar JM et al., The roles of vitamin C in skin health, Nutrients 2017;9(8):866 — concluded topical efficacy "poorly understood"; supports dietary vitamin C

2017Mechanism onlyPMID:28805671View source ↗

Lee JH et al., Effects of VitabridC12 on Skin Inflammation, Annals of Dermatology 2017

2017Mechanism onlyPMID:28966510View source ↗

MFDS Approved Functional Cosmetic Active — Ascorbic Acid and derivatives (whitening). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List — L-ascorbic acid and stabilized derivatives (Magnesium Ascorbyl Phosphate, Ethyl Ascorbic Acid, Sodium Ascorbyl Phosphate) are approved whitening actives in the Korean Functional Cosmetics Codex; authorized concentrations documented in Jeon JS et al., International Journal of Cosmetic Science 2016;38(3):286-93 (PMID:26564311)

2016Regulatory approvalMFDS:AscorbicAcid-WhiteningView source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Benzoyl peroxide breaks down vitamin C, making both less effective. Use one in the morning and the other at night.

  • Vitamin C and retinol work best at different pH levels. Use vitamin C in the morning and retinol at night.

  • Sensitive skin may flush.

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