Moderate evidence

Resveratrol for Melasma

A grape-derived antioxidant that defends skin from daily oxidative damage and helps even out tone. Often paired with vitamins C and E in nighttime serums.

Why it works for Melasma

Fades patches by slowing pigment production and quieting the signals that tell your skin to make more pigment. It is often paired with vitamin C in nighttime brightening serums for the upkeep phase of melasma.

How Resveratrol works

Polyphenolic stilbene that scavenges reactive oxygen species, activates SIRT1, and inhibits tyrosinase and downstream melanogenic signaling.

Evidence

4 citations from our ingredient database. Full citation list on the Resveratrol ingredient page.

journal2024

Shi Y, Shen C, Zhang W, Efficacy and safety of a topical skincare regimen containing CE Ferulic serum and resveratrol BE serum following ablative fractional CO2 laser treatment, Journal of the European Academy of Dermatology and Venereology 2024;38 Suppl 6:18-25 — split-face RCT, resveratrol-containing serum reduced erythema and accelerated wound healing post-laser

review2019

Boo YC, Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications, Antioxidants (Basel) 2019;8(9):332

journal2016

Farris P, Zeichner J, Berson D, Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol, Journal of Drugs in Dermatology 2016;15(7):863-8

journal2015

Choi DI et al., Ethanol Extract of Peanut Sprout Exhibits a Potent Anti-Inflammatory Activity, Annals of Dermatology 2015;27(2):142-151 — peanut sprout extract (high trans-resveratrol content, 176.75 µg/mL) suppressed COX-2 and NGF and inhibited NF-kB signaling in contact dermatitis model

Full Resveratrol guide →Melasma overview →