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Shop Mediheal Madecassoside Essential Face Mask 10 Sheets for Sensitive Skin
Treatment
Mediheal

Madecassoside Essential Face Mask 10 Sheets for Sensitive Skin

~$22
RednessVisible poresDark spotsRadiance

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • NiacinamideStrong evidenceFull dossier ↗

    A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

    Good for: Brightening, Barrier repair, Anti-inflammatory

  • GlycerinModerate evidenceFull dossier ↗

    A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

    Good for: Hydrating

  • Centella AsiaticaModerate evidenceFull dossier ↗

    Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.

    Good for: Anti-inflammatory, Barrier repair

  • MadecassosideModerate evidenceFull dossier ↗

    A purified compound from the cica (centella) plant, laser-focused on calming inflammation and speeding up how fast skin recovers.

    Good for: Anti-inflammatory, Barrier repair

  • PHAModerate evidenceFull dossier ↗

    The mildest exfoliating acid. Refines texture and hydrates at the same time, and it's sensitive-skin friendly.

    Good for: Exfoliating, Hydrating

  • ResveratrolModerate evidenceFull dossier ↗

    A grape-derived antioxidant that defends skin from daily oxidative damage and helps even out tone. Often paired with vitamins C and E in nighttime serums.

    Good for: Antioxidant, Anti-aging, Brightening

  • AsiaticosideModerate evidenceFull dossier ↗

    Another cica (centella) compound. This one specifically pushes collagen production, so the benefit is more about firmness than calming.

    Good for: Anti-aging, Anti-inflammatory

  • Aloe VeraModerate evidenceFull dossier ↗

    Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

    Good for: Anti-inflammatory, Hydrating

New to this? Patch test on your inner arm for 24 to 48 hours before applying to your face. If you have sensitive skin or rosacea, start 2 to 3 times per week and build up slowly.

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

NiacinamideStrong evidence10 citations

A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278444View source ↗

Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026

2026Positive (efficacy)PMID:41240206View source ↗

Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025

2025Positive (efficacy)PMID:39171587View source ↗
GlycerinModerate evidence6 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive (efficacy)PMID:35167133View source ↗

Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin

2021Positive (efficacy)PMID:31869257View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive (efficacy)PMID:28889318View source ↗
Centella AsiaticaModerate evidence6 citations

Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.

Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026

2026Positive (efficacy)PMID:42196964View source ↗

Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026

2026Mechanism onlyPMID:42280293View source ↗

Witkowska K et al., Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy, Pharmaceutics 2024;16(10):1252 — modern hydrogel and nanostructured Centella delivery systems accelerate wound healing across wound types

2024Meta-analysis (positive)PMID:39458583View source ↗
+5 more ingredients
MadecassosideModerate evidence6 citations

A purified compound from the cica (centella) plant, laser-focused on calming inflammation and speeding up how fast skin recovers.

Liu L et al., Madecassoside Attenuated UVB Irradiation-Induced Skin Ferroptosis by Targeting POR, Phytomedicine 2026

2026Mechanism onlyPMID:41421280View source ↗

Bandopadhyay S et al., Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review, Journal of Cellular and Molecular Medicine 2023;27(5):593-608 — comprehensive review of wound-healing, anti-inflammatory and regenerative activity

2023Meta-analysis (positive)PMID:36756687View source ↗

Park KS, Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms, Evidence-Based Complementary and Alternative Medicine 2021;2021:5462633 — KR-authored review of triterpenes including madecassoside

2021Meta-analysis (positive)PMID:34845411View source ↗
PHAModerate evidence5 citations

The mildest exfoliating acid. Refines texture and hydrates at the same time, and it's sensitive-skin friendly.

Peng Y et al., Comparison of Efficacy and Willingness to a 5% Gluconolactone-Based Topical Serum and Intense Pulsed Light in Mild Erythema of Rosacea: A Paired Control Study, Journal of Cosmetic Dermatology 2025;24(3):e70025 — 5% gluconolactone serum improved erythema and moisturization over 30 days

2025Positive (efficacy)PMID:40111222View source ↗

Kantikosum K et al., The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris, Clinical Cosmetic and Investigational Dermatology 2019;12:151-161 — gluconolactone cosmeceutical added benefit on top of adapalene without hindering treatment

2019Positive (efficacy)PMID:30858720View source ↗

Edison BL et al., A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen, Cutis 2004;73(2 Suppl):14-17 — 12-week PHA regimen matched AHA antiaging benefits with significantly less stinging/burning

2004Positive (efficacy)PMID:15002657View source ↗
ResveratrolModerate evidence6 citations

A grape-derived antioxidant that defends skin from daily oxidative damage and helps even out tone. Often paired with vitamins C and E in nighttime serums.

Shi Y, Shen C, Zhang W, Efficacy and safety of a topical skincare regimen containing CE Ferulic serum and resveratrol BE serum following ablative fractional CO2 laser treatment, Journal of the European Academy of Dermatology and Venereology 2024;38 Suppl 6:18-25 — split-face RCT, resveratrol-containing serum reduced erythema and accelerated wound healing post-laser

2024Positive (efficacy)PMID:38828801View source ↗

Hecker A et al., The impact of resveratrol on skin wound healing, scarring, and aging, International Wound Journal 2022;19(1):9-28 — review of resveratrol's dermatological effects on wound healing, scarring, and photoaging

2022Mechanism onlyPMID:33949795View source ↗

Lin MH et al., The bioactivities of resveratrol and its naturally occurring derivatives on skin, Journal of Food and Drug Analysis 2021;29(1):15-38 — review of cutaneous resveratrol activity in photoaging, melanogenesis, and dermatitis

2021Mechanism onlyPMID:35696226View source ↗
AsiaticosideModerate evidence7 citations

Another cica (centella) compound. This one specifically pushes collagen production, so the benefit is more about firmness than calming.

Bandopadhyay S et al., Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review, Journal of Cellular and Molecular Medicine 2023;27(5):593-608 — asiaticoside and madecassoside have wound healing, anti-inflammatory, and dermatological potential

2023Mechanism onlyPMID:36756687View source ↗

Park KS, Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms, Evidence-Based Complementary and Alternative Medicine 2021;2021:5462633 — documents asiaticoside efficacy across wound healing, scarring and inflammatory dermatoses

2021Meta-analysis (positive)PMID:34845411View source ↗

Peng Q et al., Transdermal characteristics and mechanism of asiaticoside nanoemulsions and asiaticoside nanoemulsions-based gels, Zhongguo Zhong Yao Za Zhi (China Journal of Chinese Materia Medica) 2018;43(9):1857-1863 — asiaticoside nanoemulsions achieved 6-7x greater drug permeation and 5-6x greater skin deposition vs commercial cream

2018Mechanism onlyPMID:29902897View source ↗
Aloe VeraModerate evidence7 citations

Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

Huang YN et al., Effects of Aloe vera on Burn Injuries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Burn Care & Research 2024;45(6):1536-1545 — topical aloe vera reduced burn wound-healing time

2024Meta-analysis (positive)PMID:38605441View source ↗

Tungkasamit T et al., Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial, European Journal of Oncology Nursing 2022;59:102164 — aloe vera reduced severity of moderate-to-severe radiation dermatitis

2022Positive (efficacy)PMID:35767935View source ↗

Sharma S et al., Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review, Advances in Skin & Wound Care 2022;35(11):1-9 — topical aloe vera shortened time to healing for second-degree burns

2022Meta-analysis (positive)PMID:36264753View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

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