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Shop Clinique Smart Clinical Repair Wrinkle Correcting Serum
Serum
Clinique

Smart Clinical Repair Wrinkle Correcting Serum

~$80· 1 fl oz
Fine lines & firmnessDrynessUneven texture

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • Hyaluronic AcidStrong evidenceFull dossier ↗

    A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

    Good for: Hydrating

  • Matrixyl PeptidesModerate evidenceFull dossier ↗

    Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

    Good for: Anti-aging

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Hyaluronic AcidStrong evidence7 citations

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.

2025Meta-analysis (positive)PMID:40990743View source ↗

Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis (positive)PMID:36200921View source ↗

Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020

2020Mechanism onlyPMID:33911737View source ↗
Matrixyl PeptidesModerate evidence6 citations

Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles

2024Positive (efficacy)PMID:38932444View source ↗

Aruan RR et al., Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet, Journal of Clinical and Aesthetic Dermatology 2023;16(2):37-43 — RCT of topical palmitoyl pentapeptide-4 (Matrixyl) for periorbital wrinkles

2023Positive (efficacy)PMID:36909866View source ↗

Imhof L, Leuthard D, Topical Over-the-Counter Antiaging Agents: An Update and Systematic Review, Dermatology 2021;237(2):217-229 — SR covering topical antiaging peptides

2021Meta-analysis (positive)PMID:32882685View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

Full ingredient list

Everything on the package label, not just the tracked actives above.

Fragrance freeDrying alcohol freeSulfates freeParabens free
  • Contains silicones: Dimethicone, Polysilicone-11, PEG-10 DimethiconeNo irritancy evidence. CIR rates this safe as used; some shoppers avoid it by preference.
+Show all 53 ingredients

Listed in the order printed on the package. By regulation, ingredients at 1% or higher are listed in descending order by concentration, so the first entry is the largest part of the formula.

  1. Water\Aqua\Eau
  2. Dimethicone
  3. Isododecane
  4. Butylene Glycol
  5. Glycerin
  6. Polysilicone-11
  7. Ascorbyl Glucoside
  8. Sodium Hyaluronate
  9. Tocopheryl Acetate
  10. Squalane
  11. Hypnea Musciformis (Algae) Extract
  12. Gelidiella Acerosa Extract
  13. Sigesbeckia Orientalis (St. Paul'S Wort) Extract
  14. Helianthus Annuus (Sunflower) Seed Extract
  15. Hordeum Vulgare (Barley) Extract\Extrait D'Orge
  16. Triticum Vulgare (Wheat) Germ Extract
  17. Cucumis Sativus (Cucumber) Fruit Extract
  18. Caffeine
  19. Acetyl Hexapeptide-8
  20. Palmitoyl Tripeptide-1
  21. Palmitoyl Tetrapeptide-7
  22. Palmitoyl Hexapeptide-12
  23. PEG-10 Dimethicone
  24. Glycyrrhetinic Acid
  25. Whey Protein\Lactis Protein\Protéine Du Petit-Lait
  26. Isohexadecane
  27. Propylene Glycol Dicaprate
  28. Caprylyl Glycol
  29. Hydroxypinacolone Retinoate
  30. Acetyl Glucosamine
  31. Cholesterol
  32. PEG-8
  33. Yeast Extract\Faex\Extrait De Levure
  34. PEG-6
  35. Dimethyl Isosorbide
  36. Glyceryl Polymethacrylate
  37. Polysorbate 20
  38. Sodium Phosphate
  39. Synthetic Fluorphlogopite
  40. Polysorbate 80
  41. Carbomer
  42. Hexylene Glycol
  43. Ammonium Acryloyldimethyltaurate/​VP Copolymer
  44. Acrylamide/​Sodium Acryloyldimethyltaurate Copolymer
  45. Potassium Hydroxide
  46. Tin Oxide
  47. Disodium Phosphate
  48. Citric Acid
  49. Disodium EDTA
  50. Sodium Citrate
  51. Phenoxyethanol
  52. Potassium Sorbate
  53. Titanium Dioxide (Ci 77891)

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Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.