Shop Medicube Age-R Vita C Pro Ampoule Vitamin C 30ml
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Age-R Vita C Pro Ampoule Vitamin C 30ml

~$34· 30ml
Dark spotsFine lines & firmnessRadianceDryness

Evidence behind the ingredients

Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Vitamin CStrong evidence14 citations

Brightens dull skin and helps fade dark spots. Also defends against everyday UV and pollution damage when worn under sunscreen.

Pullar JM et al., The roles of vitamin C in skin health, Nutrients 2017;9(8):866 — concluded topical efficacy "poorly understood"; supports dietary vitamin C

2017Mechanism onlyPMID:28805671View source ↗

Lee JH et al., Effects of VitabridC12 on Skin Inflammation, Annals of Dermatology 2017

2017Mechanism onlyPMID:28966510View source ↗

MFDS Approved Functional Cosmetic Active — Ascorbic Acid and derivatives (whitening). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List — L-ascorbic acid and stabilized derivatives (Magnesium Ascorbyl Phosphate, Ethyl Ascorbic Acid, Sodium Ascorbyl Phosphate) are approved whitening actives in the Korean Functional Cosmetics Codex; authorized concentrations documented in Jeon JS et al., International Journal of Cosmetic Science 2016;38(3):286-93 (PMID:26564311)

2016Regulatory approvalMFDS:AscorbicAcid-WhiteningView source ↗
Ferulic AcidModerate evidence5 citations

Boosts the effectiveness of vitamin C and vitamin E when layered together. The reason a good morning antioxidant serum stays potent through the day.

Kim JH et al., Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial, Journal of Dermatological Treatment 2025;36(1):2504655 — CE+ferulic serum + microneedle RF produced superior clinical and histologic neck rejuvenation vs RF alone

2025Positive — efficacyPMID:40464749View source ↗

Hahn HJ et al., Pretreatment of Ferulic Acid Protects Human Dermal Fibroblasts against Ultraviolet A Irradiation, Annals of Dermatology 2016;28(6):740-748 — ferulic acid pretreatment protects human dermal fibroblasts from UVA damage via antioxidant + stress-inducible mechanisms

2016Mechanism onlyPMID:27904274View source ↗

Staniforth V et al., Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin via posttranslational mechanisms, Journal of Nutritional Biochemistry 2012;23(5):443-451 — ferulic acid suppressed UVB-induced MMP-2/-9 expression

2012Mechanism onlyPMID:21543204View source ↗
Licorice RootModerate evidence8 citations

A gentle Asian-skincare brightener derived from licorice root. Fades dark spots and calms redness, and it's a pregnancy-safe alternative to stronger fade ingredients.

Glabridin Inhibits Melanogenesis and Melanin Transfer via Wnt/beta-Catenin Pathway and Rho Family GTPase-Mediated Dendritic Formation Suppression, Pharmaceuticals (Basel) 2026;19(3) — glabridin (the licorice-root active) suppressed melanin synthesis and keratinocyte melanin transfer in vitro via Wnt/beta-Catenin and Rho-GTPase dendrite suppression

2026Mechanism onlyPMID:41901315View source ↗

Liu Y et al., Glycyrrhiza glabra extract as a skin-whitening agent: Identification of active components and CRTC1/MITF pathway-inhibition mechanism, Journal of Ethnopharmacology 2025;349:119948 — identifies glabridin as the principal active and maps skin-whitening mechanism via CREB/CRTC1/MITF suppression

2025Mechanism onlyPMID:40350048View source ↗

Wang JY et al., Preparation of compound liquorice microemulsion gel and its pharmacodynamics evaluation, Zhongguo Zhong Yao Za Zhi (China Journal of Chinese Materia Medica) 2020;45(21):5193-5199 — compound licorice (Glycyrrhiza) microemulsion gel significantly reduced ear swelling and inflammatory infiltration in chronic eczema mouse model

2020Positive — efficacyPMID:33350235View source ↗
+3 more ingredients
Beta-GlucanModerate evidence4 citations

A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.

Feng X et al., Exploring the Properties and Application Potential of beta-Glucan in Skin Care, Food Science and Nutrition 2025;13(4):e70212 — review concludes beta-glucan exhibits antioxidant, anti-inflammatory, barrier repair, and moisturizing bioactivities

2025Mechanism onlyPMID:40291929View source ↗

Kussie HC et al., Avenanthramide and beta-Glucan Therapeutics Accelerate Wound Healing Via Distinct and Nonoverlapping Mechanisms, Advances in Wound Care 2024;13(4):155-166 — in vivo: beta-glucan accelerated wound closure with increased angiogenesis

2024Positive — efficacyPMID:38299969View source ↗

Du B et al., Oat β-glucan ameliorates epidermal barrier disruption by upregulating CaSR via dectin-1-mediated ERK/p38 signaling, International Journal of Biological Macromolecules 2021 — mechanism for barrier-repair effects; in-vitro and animal-model evidence

2021Mechanism onlyPMID:34237364View source ↗
Coenzyme Q10Moderate evidence5 citations

A naturally-occurring antioxidant your skin loses as you age. Topical CoQ10 restores some of what time depletes, supporting energy production in skin cells and softening wrinkle depth.

Li S et al., Ginsenoside Nanoliposomes Deliver Ergothioneine and Coenzyme Q10 to Address Skin Aging via Mitochondrial Mechanisms, Colloids and Surfaces B: Biointerfaces 2026

2026Mechanism onlyPMID:41475077View source ↗

Lain ET, Agrawal N, Ruvolo E, Weise JM, Callender VD, The Role of Coenzyme Q10 in Skin Aging and Opportunities for Topical Intervention: A Review, Journal of Clinical and Aesthetic Dermatology 2024;17(8):42-47

2024Positive — efficacyPMID:39148958View source ↗

Ayunin Q, Miatmoko A, Soeratri W, Erawati T, Susanto J, Legowo D, Improving the anti-ageing activity of coenzyme Q10 through protransfersome-loaded emulgel, Scientific Reports 2022;12(1):906 — topical CoQ10 protransfersomal emulgel increased collagen density and fibroblast count in UV-aged mouse skin

2022Positive — efficacyPMID:35042910View source ↗
PanthenolModerate evidence5 citations

Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.

Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline

2025Positive — efficacyPMID:40613435View source ↗

Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD

2022Meta-analysis — positivePMID:35887707View source ↗

Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser

2019Positive — efficacyPMID:30897983View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Benzoyl peroxide breaks down vitamin C, making both less effective. Use one in the morning and the other at night.

  • Vitamin C and retinol work best at different pH levels. Use vitamin C in the morning and retinol at night.

  • Sensitive skin may flush.

Similar comparisons

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