Shop MEDIHEAL Collagen Ampoule Toner Pads (100 Count)
Toner
MEDIHEAL

Collagen Ampoule Toner Pads (100 Count)

~$16
DrynessRednessFine lines & firmness

Evidence behind the ingredients

Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

CeramidesStrong evidence8 citations

Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control

2025Positive — efficacyPMID:40408261View source ↗

Kawamoto A et al., Chain length of covalently bound ceramides correlates with skin barrier function in healthy subjects, Journal of Dermatological Science 2023;110(1):35-38 — clinical study: SC ceramide chain length directly correlates with barrier function; longer-chain ceramides are the functionally relevant species

2023Mechanism onlyPMID:37002180View source ↗

Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults

2022Positive — efficacyPMID:35298858View source ↗
Matrixyl PeptidesModerate evidence6 citations

Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles

2024Positive — efficacyPMID:38932444View source ↗

Lintner K, Gerstein F, Solish N, A serum containing vitamins C and E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos analysis, Journal of Cosmetic Dermatology 2020;19(12):3262-3269 — matrix-repair tripeptide serum: 8-9% roughness reduction, 9% redness reduction by Primos imaging

2020Positive — efficacyPMID:33103342View source ↗

Bae JS et al., Topical application of palmitoyl-RGD reduces human facial wrinkle formation in Korean women, Archives of Dermatological Research 2017;309(8):665-671 — palmitoylated peptide reduced wrinkle formation via collagen activation and protection from degradation

2017Positive — efficacyPMID:28752204View source ↗
AdenosineModerate evidence7 citations

A Korean-approved anti-wrinkle ingredient that encourages collagen production for a smoother, firmer look.

Nguyen NH et al., Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278371View source ↗

MFDS Approved Functional Cosmetic Active — Adenosine (anti-wrinkle). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List

2020Regulatory approvalMFDS:Adenosine-AntiWrinkleView source ↗

Jang M et al., Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity, International Journal of Cosmetic Science 2020;42(3):302-309 — Korean comparison: HMW HA + adenosine outperformed LMW HA across wrinkle and elasticity parameters

2020Positive — efficacyPMID:32421218View source ↗
+3 more ingredients
AllantoinModerate evidence6 citations

A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.

Xu Z et al., Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel for the Treatment of Rosacea, Journal of Cosmetic Dermatology 2025;24(4):e70129 — RCT (n=82, 12 weeks): allantoin gel improved erythema and alleviated itching/burning vs traditional therapy

2025Positive — efficacyPMID:40177799View source ↗

Tan C et al., The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes, International Journal of Cosmetic Science 2024;46(5):691-701 — in vitro: allantoin combination reduced UVB-induced PGE2, IL-1α, IL-6, IL-8, TNFα

2024Mechanism onlyPMID:38433250View source ↗

Saucedo-Acuna RA et al. (Mexico), Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds, International Journal of Molecular Sciences 2023;24(8):7377 — allantoin-pectin hydrogel reduced wound healing time by ~71% with complete closure at day 15 in rat model

2023Mechanism onlyPMID:37108540View source ↗
GlycerinModerate evidence4 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive — efficacyPMID:35167133View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive — efficacyPMID:28889318View source ↗

Fluhr JW et al., Glycerol and the skin: holistic approach to its origin and functions, British Journal of Dermatology 2008;159(1):23-34 — improves xerosis and barrier function

2008Positive — efficacyPMID:18510666View source ↗
Copper PeptidesModerate evidence6 citations

A signal peptide that tells your skin to make more collagen and elastin. Quiet but consistent firmness support over months of daily use.

Patel MN et al., An Assessment of the Safety, Efficacy, and Tolerability of a Novel Scalp Treatment Regimen Combining a Hydroxy Acid-Based Scrub and Copper Tripeptide Serum in the Management of Seborrheic Dermatitis in Adults, Cureus 2024;16(9):e70108 — 15-day interventional study: copper tripeptide regimen reduced flaking, improved hydration in seborrheic dermatitis

2024Positive — efficacyPMID:39449909View source ↗

Jiang F et al., Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests, Journal of Cosmetic Dermatology 2023;22(9):2598-2604 — in vitro + ex vivo: GHK-Cu + HA promoted collagen I, IV, and VII; 25.4-fold collagen IV increase in fibroblasts

2023Mechanism onlyPMID:37062921View source ↗

Dou Y et al., The potential of GHK as an anti-aging peptide, Aging Pathobiology and Therapeutics 2020;2(1):58-61 — narrative review of GHK-Cu's anti-inflammatory and tissue-remodeling mechanisms

2020Mechanism onlyPMID:35083444View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.

Similar comparisons

← Back to shop

Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.