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Shop Paula's Choice Pro-Collagen Peptide Plumping Moisturizer
Moisturizer
Paula's Choice

Pro-Collagen Peptide Plumping Moisturizer

~$49· 1.7 oz
Fine lines & firmness

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • Matrixyl PeptidesModerate evidenceFull dossier ↗

    Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

    Good for: Anti-aging

  • Hyaluronic AcidStrong evidenceFull dossier ↗

    A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

    Good for: Hydrating

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Matrixyl PeptidesModerate evidence6 citations

Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles

2024Positive (efficacy)PMID:38932444View source ↗

Aruan RR et al., Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet, Journal of Clinical and Aesthetic Dermatology 2023;16(2):37-43 — RCT of topical palmitoyl pentapeptide-4 (Matrixyl) for periorbital wrinkles

2023Positive (efficacy)PMID:36909866View source ↗

Imhof L, Leuthard D, Topical Over-the-Counter Antiaging Agents: An Update and Systematic Review, Dermatology 2021;237(2):217-229 — SR covering topical antiaging peptides

2021Meta-analysis (positive)PMID:32882685View source ↗
Hyaluronic AcidStrong evidence7 citations

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.

2025Meta-analysis (positive)PMID:40990743View source ↗

Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis (positive)PMID:36200921View source ↗

Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020

2020Mechanism onlyPMID:33911737View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

Full ingredient list

Everything on the package label, not just the tracked actives above.

Fragrance freeDrying alcohol freeSulfates freeParabens free
  • Contains silicones: DimethiconeNo irritancy evidence. CIR rates this safe as used; some shoppers avoid it by preference.
+Show all 22 ingredients

Listed in the order printed on the package. By regulation, ingredients at 1% or higher are listed in descending order by concentration, so the first entry is the largest part of the formula.

  1. Aqua/​Water/​Eau
  2. Dimethicone
  3. Squalane
  4. Glycerin
  5. Pyrus Malus (Apple) Fruit Extract
  6. Pentylene Glycol
  7. 1, 2-Hexanediol
  8. Ammonium Acryloyldimethyltaurate/​VP Copolymer
  9. Butylene Glycol
  10. Hydroxyacetophenone
  11. Sodium Acrylates Copolymer
  12. Acrylates/​C10-30 Alkyl Acrylate Crosspolymer
  13. Gigartina Stellata Extract
  14. Acetyl SH-Hexapeptide-5 Amide Acetate
  15. Tridecapeptide-1
  16. Oligopeptide-1
  17. Sodium Phytate
  18. Propanediol
  19. Lecithin
  20. Hydroxypropyltrimonium Hyaluronate
  21. Cyanocobalamin
  22. Phenoxyethanol

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