Pro-balance Biotics Moisturiser
What it's good for
Key actives from our research database. Click any to read the full evidence dossier.
A Korean-approved anti-wrinkle ingredient that encourages collagen production for a smoother, firmer look.
Good for: Anti-aging
A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.
Good for: Hydrating, Anti-inflammatory
A probiotic-based ingredient that strengthens your skin's defenses against irritation and environmental stress.
Good for: Barrier repair, Anti-inflammatory
The "calm-down" molecule in many sensitive-skin formulas. Reduces redness and stinging without bleaching your barrier, and plays nicely on top of retinoids or exfoliating acids.
Good for: Anti-inflammatory
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Good for: Anti-inflammatory, Barrier repair
Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.
Good for: Barrier repair
The third (and most often missing) lipid in the skin barrier triumvirate. Without it, even ceramide-heavy creams underperform. Topping it up is what lets compromised, aged, or eczema-prone skin actually rebuild its waterproof layer.
Good for: Barrier repair
A "master antioxidant" your body already makes. In skincare it gently lightens overall tone and helps fade pigmentation when used consistently over months.
Good for: Brightening, Antioxidant
A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.
Good for: Hydrating
A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.
Good for: Hydrating
A "postbiotic" (dead probiotic bits) that talks to your skin microbiome without adding live bugs. Patches up a leaky barrier and is friendly even on very reactive skin.
Good for: Barrier repair, Hydrating
Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.
Good for: Anti-aging
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Good for: Hydrating, Barrier repair
Evidence behind the ingredients
Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
A Korean-approved anti-wrinkle ingredient that encourages collagen production for a smoother, firmer look.
Yang HJ et al., Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement, Journal of Cosmetic Dermatology 2019;18(3):936-943 — Korean clinical study (n=20): adenosine microneedle patches improved elasticity, hydration, dermal density, wrinkles
Kang G et al., Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration, International Journal of Cosmetic Science 2018;40(2):199-206 — Korean-authored; adenosine microneedle patches matched or exceeded adenosine cream for multiple endpoints
Kim MY et al., Effect of adenosine on melanogenesis in B16 cells and zebrafish, Annals of Dermatology 2014;26(2):209-13 — adenosine suppresses pigmentation via negative regulation of tyrosinase in cellular and zebrafish models
A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.
Feng X et al., Exploring the Properties and Application Potential of beta-Glucan in Skin Care, Food Science and Nutrition 2025;13(4):e70212 — review concludes beta-glucan exhibits antioxidant, anti-inflammatory, barrier repair, and moisturizing bioactivities
Kussie HC et al., Avenanthramide and beta-Glucan Therapeutics Accelerate Wound Healing Via Distinct and Nonoverlapping Mechanisms, Advances in Wound Care 2024;13(4):155-166 — in vivo: beta-glucan accelerated wound closure with increased angiogenesis
Cao Y et al., Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser, Journal of Dermatology 2022;49(9):829-836 — RCT; topical beta-glucan twice daily for 12 weeks on stretch marks
A probiotic-based ingredient that strengthens your skin's defenses against irritation and environmental stress.
Zhu X et al., Protective effect of Bifidobacterium animalis CGMCC25262 on HaCaT keratinocytes, International Microbiology 2024;27(5):1417-1428 — B. animalis lysate upregulated HAS-2, AQP3, FLG and reduced RANTES under TNF-α/IFN-γ
Wang Y et al., Short-term skin reactions and changes in stratum corneum following different ways of facial sheet mask usage, Journal of Tissue Viability 2024;33(4):831-839 — evaluated topical bifida ferment lysate masks on skin barrier measures
Wang R et al., The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro, Journal of Cosmetic Dermatology 2023;22(12):3427-3435 — BFL upregulated barrier and antioxidant genes; reduced inflammatory signaling
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The "calm-down" molecule in many sensitive-skin formulas. Reduces redness and stinging without bleaching your barrier, and plays nicely on top of retinoids or exfoliating acids.
Wu Y et al., Exploring the mechanism of alpha-Bisabolol in the treatment of psoriasis based on network pharmacology and experimental validation, European Journal of Pharmacology 2025 — alpha-bisabolol suppressed inflammation in TNF-alpha-treated keratinocytes and psoriasis mice via PI3K/AKT and NF-kB pathways; reduced IL-6, IL-1beta, TNF-alpha and skin lesions
Karami H et al. (Brazil), Development of a hydrogel containing bisabolol-loaded nanocapsules for the treatment of atopic dermatitis in a Balb/c mice model, International Journal of Pharmaceutics 2024
Tan C et al. (Brazil), The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes, International Journal of Cosmetic Science 2024
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026
Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026
Witkowska K et al., Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy, Pharmaceutics 2024;16(10):1252 — modern hydrogel and nanostructured Centella delivery systems accelerate wound healing across wound types
Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.
Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control
Nugroho WT, Sawitri, Astindari, Utomo B, Listiawan MY, Ervianti E, Astari L. The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis. Indian J Dermatol. 2023;68(1):53-58. — Meta-analysis of 5 studies found ceramide-containing moisturisers produced significantly greater improvement in SCORAD compared with non-ceramide moisturisers in atopic dermatitis.
Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults
The third (and most often missing) lipid in the skin barrier triumvirate. Without it, even ceramide-heavy creams underperform. Topping it up is what lets compromised, aged, or eczema-prone skin actually rebuild its waterproof layer.
Sugarman JL, Parish LC. Efficacy of a lipid-based barrier repair formulation in moderate-to-severe pediatric atopic dermatitis. J Drugs Dermatol. 2009;8(12):1106-1111. — ceramide/cholesterol/fatty-acid triple-lipid formulation reduced disease severity, pruritus and improved sleep at days 14 and 28.
Chamlin SL, Kao J, Frieden IJ, Sheu MY, Fowler AJ, Fluhr JW, Williams ML, Elias PM. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol. 2002;47(2):198-208. — physiologic ceramide:cholesterol:fatty-acid lipid mixture; SCORAD improved significantly in 22 of 24 patients.
Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM. Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol. 1997;37(3 Pt 1):403-408.
A "master antioxidant" your body already makes. In skincare it gently lightens overall tone and helps fade pigmentation when used consistently over months.
Stanescu C et al., Glutathione in Skin Aging and Tissue Regeneration: A Systematic Review of Molecular Mechanisms, Redox Modulation, and Biomedical Implications, Molecules 2026
Sarkar R et al., Glutathione as a skin-lightening agent and in melasma: a systematic review, International Journal of Dermatology 2025
Wahab S et al., Combination of topical and oral glutathione as a skin-whitening agent: a double-blind randomized controlled clinical trial, International Journal of Dermatology 2021;60(8):1013-1018 — 8-week RCT showed combination significantly lowered melanin and raised lightness vs placebo
A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.
Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection
Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin
Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration
A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.
Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.
Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging
Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020
A "postbiotic" (dead probiotic bits) that talks to your skin microbiome without adding live bugs. Patches up a leaky barrier and is friendly even on very reactive skin.
Algieri F, Pimazzoni S et al. (Italy), Postbiotic derived from Lacticaseibacillus paracasei CNCM I-5220 as a novel approach to improve ageing-induced skin damage, Scientific Reports 2026 — 6-week topical postbiotic application reduced roughness and increased hydration, elasticity, and echogenicity vs placebo; boosted hyaluronic acid in keratinocytes and pro-collagen in fibroblasts
Flores Rodriguez JC et al. (Mexico/Colombia/Costa Rica), Postbiotics in Dermatology: A Literature Review of Emerging Topical Therapies for Acne, Rosacea, and Eczema, Cureus 2026;18(3) — review of 16 studies: postbiotics improved SCORAD and barrier function in atopic dermatitis; reduced inflammatory acne lesions 50-70% and suppressed sebum 42-72%
Flint E et al., Topical Probiotics Reduce Atopic Dermatitis Severity: A Systematic Review and Meta-Analysis, Cureus 2024;16(9):e70001 — SR/MA of topical Lactobacillus probiotics for atopic dermatitis
Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.
Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles
Aruan RR et al., Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet, Journal of Clinical and Aesthetic Dermatology 2023;16(2):37-43 — RCT of topical palmitoyl pentapeptide-4 (Matrixyl) for periorbital wrinkles
Imhof L, Leuthard D, Topical Over-the-Counter Antiaging Agents: An Update and Systematic Review, Dermatology 2021;237(2):217-229 — SR covering topical antiaging peptides
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline
Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD
Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.
Similar comparisons
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