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Shop Neogen Black Volume Cream
Moisturizer
Neogen

Black Volume Cream

~$27· 2.7 Ounce (Pack of 1)

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • AdenosineModerate evidenceFull dossier ↗

    A Korean-approved anti-wrinkle ingredient that encourages collagen production for a smoother, firmer look.

    Good for: Anti-aging

  • Aloe VeraModerate evidenceFull dossier ↗

    Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

    Good for: Anti-inflammatory, Hydrating

  • Alpha-Lipoic AcidModerate evidenceFull dossier ↗

    A "universal antioxidant" that protects both the oily and watery parts of your skin. It's unique because it can recycle your Vitamin C and E, making them last longer. It also prevents "sugar-sag" (glycation) and reduces fine lines.

    Good for: Antioxidant, Anti-aging

  • Argan OilModerate evidenceFull dossier ↗

    The Moroccan kitchen-staple oil with real cosmetic data behind it. Daily use measurably improves skin elasticity in postmenopausal women. Good for dry, mature, or barrier-compromised skin without feeling greasy.

    Good for: Hydrating, Barrier repair, Antioxidant

  • Beta-GlucanModerate evidenceFull dossier ↗

    A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.

    Good for: Hydrating, Anti-inflammatory

  • Centella AsiaticaModerate evidenceFull dossier ↗

    Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.

    Good for: Anti-inflammatory, Barrier repair

  • CeramidesStrong evidenceFull dossier ↗

    Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

    Good for: Barrier repair

  • CholesterolStrong evidenceFull dossier ↗

    The third (and most often missing) lipid in the skin barrier triumvirate. Without it, even ceramide-heavy creams underperform. Topping it up is what lets compromised, aged, or eczema-prone skin actually rebuild its waterproof layer.

    Good for: Barrier repair

  • GlycerinModerate evidenceFull dossier ↗

    A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

    Good for: Hydrating

  • HoneyModerate evidenceFull dossier ↗

    An ancient humectant and antimicrobial ingredient with a long research track record. Its sugar matrix and flavonoids help draw in moisture and support skin comfort; formulas pairing honey with beeswax and olive oil have shown improvement in dry, irritation-prone skin in controlled trials.

    Good for: Anti-inflammatory, Anti-acne, Hydrating

  • Hyaluronic AcidStrong evidenceFull dossier ↗

    A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

    Good for: Hydrating

  • Mulberry ExtractModerate evidenceFull dossier ↗

    A "natural skin lightener" with actual clinical-trial backing for melasma. A placebo-controlled study showed real MASI improvement. Sits well alongside vitamin C, alpha-arbutin, or niacinamide in a brightening stack.

    Good for: Brightening, Antioxidant

  • N-AcetylglucosamineModerate evidenceFull dossier ↗

    A gentle brightener that fades dark spots while quietly boosting hydration. Pairs especially well with niacinamide.

    Good for: Brightening, Hydrating

  • NiacinamideStrong evidenceFull dossier ↗

    A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

    Good for: Brightening, Barrier repair, Anti-inflammatory

  • Panax GinsengStrong evidenceFull dossier ↗

    A staple in Hanbang (traditional Korean medicine) skincare. It's packed with antioxidants and ginsenosides that help firm the skin, boost circulation, and defend against environmental aging.

    Good for: Anti-aging, Antioxidant, Barrier repair

  • PropolisModerate evidenceFull dossier ↗

    A bee-made resin that's antibacterial and anti-inflammatory. Calms breakouts and hydrates at the same time.

    Good for: Anti-acne, Anti-inflammatory

  • Snow MushroomAnecdotal evidenceFull dossier ↗

    Often pitched as the gentler cousin of hyaluronic acid. It holds water in the skin, fades less quickly in dry air, and quietly buffers against UV oxidative stress.

    Good for: Hydrating, Antioxidant, Barrier repair

  • Witch HazelAnecdotal evidenceFull dossier ↗

    A botanical astringent backed by real anti-inflammatory evidence. Extracts genuinely calm acne-related inflammation by blocking the same NF-κB pathway that redness-causing cytokines depend on. Honest caveat: most shelf-ready witch hazel toners are distilled water with trace tannin; look for "Hamamelis virginiana extract" rather than "hamamelis water" on the label if you want the active fraction.

    Good for: Anti-inflammatory, Anti-acne

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

AdenosineModerate evidence6 citations

A Korean-approved anti-wrinkle ingredient that encourages collagen production for a smoother, firmer look.

Yang HJ et al., Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement, Journal of Cosmetic Dermatology 2019;18(3):936-943 — Korean clinical study (n=20): adenosine microneedle patches improved elasticity, hydration, dermal density, wrinkles

2019Positive (efficacy)PMID:30160014View source ↗

Kang G et al., Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration, International Journal of Cosmetic Science 2018;40(2):199-206 — Korean-authored; adenosine microneedle patches matched or exceeded adenosine cream for multiple endpoints

2018Positive (efficacy)PMID:29574973View source ↗

Kim MY et al., Effect of adenosine on melanogenesis in B16 cells and zebrafish, Annals of Dermatology 2014;26(2):209-13 — adenosine suppresses pigmentation via negative regulation of tyrosinase in cellular and zebrafish models

2014Mechanism onlyPMID:24882976View source ↗
Aloe VeraModerate evidence7 citations

Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

Huang YN et al., Effects of Aloe vera on Burn Injuries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Burn Care & Research 2024;45(6):1536-1545 — topical aloe vera reduced burn wound-healing time

2024Meta-analysis (positive)PMID:38605441View source ↗

Tungkasamit T et al., Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial, European Journal of Oncology Nursing 2022;59:102164 — aloe vera reduced severity of moderate-to-severe radiation dermatitis

2022Positive (efficacy)PMID:35767935View source ↗

Sharma S et al., Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review, Advances in Skin & Wound Care 2022;35(11):1-9 — topical aloe vera shortened time to healing for second-degree burns

2022Meta-analysis (positive)PMID:36264753View source ↗
Alpha-Lipoic AcidModerate evidence2 citations

A "universal antioxidant" that protects both the oily and watery parts of your skin. It's unique because it can recycle your Vitamin C and E, making them last longer. It also prevents "sugar-sag" (glycation) and reduces fine lines.

Lee WJ et al., Anti-Inflammatory and Antioxidative Effects of Alpha Lipoic Acid on Cultured Human Sebocytes, Annals of Dermatology 2019

2019Mechanism onlyPMID:33911546View source ↗

Beitner H, Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin, British Journal of Dermatology 2003;149(4):841-9

2003Positive (efficacy)PMID:14616378View source ↗
+15 more ingredients
Argan OilModerate evidence4 citations

The Moroccan kitchen-staple oil with real cosmetic data behind it. Daily use measurably improves skin elasticity in postmenopausal women. Good for dry, mature, or barrier-compromised skin without feeling greasy.

Lin TK, Zhong L, Santiago JL, Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils, International Journal of Molecular Sciences 2017;19(1):70 — review of 19 plant oils including argan: documents anti-inflammatory, antioxidant, stratum-corneum barrier-repair mechanisms

2017Mechanism onlyPMID:29280987View source ↗

Boucetta KQ et al., The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity, Clinical Interventions in Aging 2015;10:339-349 — 60-day RCT: both dietary and topical argan oil significantly increased cutometer-measured gross, net, and biological elasticity (all p<0.001) vs olive oil control

2015Positive (efficacy)PMID:25673976View source ↗

Boucetta KQ et al., Skin hydration in postmenopausal women: argan oil benefit with oral and/or topical use, Przeglad Menopauzalny 2014;13(5):280-288 — RCT; topical forearm application over 60 days significantly improved skin hydration

2014Positive (efficacy)PMID:26327867View source ↗
Beta-GlucanModerate evidence5 citations

A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.

Feng X et al., Exploring the Properties and Application Potential of beta-Glucan in Skin Care, Food Science and Nutrition 2025;13(4):e70212 — review concludes beta-glucan exhibits antioxidant, anti-inflammatory, barrier repair, and moisturizing bioactivities

2025Mechanism onlyPMID:40291929View source ↗

Kussie HC et al., Avenanthramide and beta-Glucan Therapeutics Accelerate Wound Healing Via Distinct and Nonoverlapping Mechanisms, Advances in Wound Care 2024;13(4):155-166 — in vivo: beta-glucan accelerated wound closure with increased angiogenesis

2024Positive (efficacy)PMID:38299969View source ↗

Cao Y et al., Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser, Journal of Dermatology 2022;49(9):829-836 — RCT; topical beta-glucan twice daily for 12 weeks on stretch marks

2022Positive (efficacy)PMID:35570397View source ↗
Centella AsiaticaModerate evidence6 citations

Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.

Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026

2026Positive (efficacy)PMID:42196964View source ↗

Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026

2026Mechanism onlyPMID:42280293View source ↗

Witkowska K et al., Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy, Pharmaceutics 2024;16(10):1252 — modern hydrogel and nanostructured Centella delivery systems accelerate wound healing across wound types

2024Meta-analysis (positive)PMID:39458583View source ↗
CeramidesStrong evidence7 citations

Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control

2025Positive (efficacy)PMID:40408261View source ↗

Nugroho WT, Sawitri, Astindari, Utomo B, Listiawan MY, Ervianti E, Astari L. The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis. Indian J Dermatol. 2023;68(1):53-58. — Meta-analysis of 5 studies found ceramide-containing moisturisers produced significantly greater improvement in SCORAD compared with non-ceramide moisturisers in atopic dermatitis.

2023Meta-analysis (positive)PMID:37151263View source ↗

Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults

2022Positive (efficacy)PMID:35298858View source ↗
CholesterolStrong evidence5 citations

The third (and most often missing) lipid in the skin barrier triumvirate. Without it, even ceramide-heavy creams underperform. Topping it up is what lets compromised, aged, or eczema-prone skin actually rebuild its waterproof layer.

Sugarman JL, Parish LC. Efficacy of a lipid-based barrier repair formulation in moderate-to-severe pediatric atopic dermatitis. J Drugs Dermatol. 2009;8(12):1106-1111. — ceramide/cholesterol/fatty-acid triple-lipid formulation reduced disease severity, pruritus and improved sleep at days 14 and 28.

2009Positive (efficacy)PMID:20027938View source ↗

Chamlin SL, Kao J, Frieden IJ, Sheu MY, Fowler AJ, Fluhr JW, Williams ML, Elias PM. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol. 2002;47(2):198-208. — physiologic ceramide:cholesterol:fatty-acid lipid mixture; SCORAD improved significantly in 22 of 24 patients.

2002Positive (efficacy)PMID:12140465View source ↗

Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM. Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol. 1997;37(3 Pt 1):403-408.

1997Positive (efficacy)PMID:9308554View source ↗
GlycerinModerate evidence6 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive (efficacy)PMID:35167133View source ↗

Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin

2021Positive (efficacy)PMID:31869257View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive (efficacy)PMID:28889318View source ↗
HoneyModerate evidence5 citations

An ancient humectant and antimicrobial ingredient with a long research track record. Its sugar matrix and flavonoids help draw in moisture and support skin comfort; formulas pairing honey with beeswax and olive oil have shown improvement in dry, irritation-prone skin in controlled trials.

Semprini A, Braithwaite I, Corin A, et al. Randomised controlled trial of topical kanuka honey for the treatment of acne. BMJ Open. 2016 Feb 1;6(2):e009448. — RCT: kanuka honey + antibacterial soap was NOT significantly more effective than antibacterial soap alone for acne; primary endpoint not met.

2016InconclusivePMID:26832428View source ↗

Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;(3):CD005083.

2015Meta-analysis (mixed)PMID:25742878View source ↗

Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011;1(2):154-160.

2011Mechanism onlyPMID:23569748View source ↗
Hyaluronic AcidStrong evidence7 citations

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.

2025Meta-analysis (positive)PMID:40990743View source ↗

Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis (positive)PMID:36200921View source ↗

Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020

2020Mechanism onlyPMID:33911737View source ↗
Mulberry ExtractModerate evidence4 citations

A "natural skin lightener" with actual clinical-trial backing for melasma. A placebo-controlled study showed real MASI improvement. Sits well alongside vitamin C, alpha-arbutin, or niacinamide in a brightening stack.

Prasawang N, Sutjarit N, Sitthipunya A, et al. Inhibition of Tyrosinase and Melanogenesis by a White Mulberry Fruit Extract. International Journal of Molecular Sciences. 2025 Aug 6;26(15):7589. — Demonstrated dose-dependent inhibition of tyrosinase activity and melanogenesis by white mulberry crude extract in B16F10 cells and zebrafish embryos without cytotoxicity.

2025Mechanism onlyPMID:40806718View source ↗

Goelzer Neto CF et al., Natural sources of melanogenic inhibitors: A systematic review, International Journal of Cosmetic Science 2022;44(2):143-153 — SR identifying Morus alba (mulberry) as a notable melanogenesis inhibitor

2022Meta-analysis (positive)PMID:35048395View source ↗

Zhang L et al., Moraceae Plants with Tyrosinase Inhibitory Activity: A Review, Mini Reviews in Medicinal Chemistry 2017;17(13):1148-1157 — Morus alba and related Moraceae compounds demonstrate enzymatic tyrosinase inhibition and clinical whitening effects competitive with available depigmenting agents

2017Mechanism onlyPMID:27292779View source ↗
N-AcetylglucosamineModerate evidence5 citations

A gentle brightener that fades dark spots while quietly boosting hydration. Pairs especially well with niacinamide.

Schlessinger J, Green B, Edison BL, Murphy L, Sabherwal Y, A Firming Neck Cream Containing N-Acetyl Glucosamine Significantly Improves Signs of Aging on the Challenging Neck and Decolletage, Journal of Drugs in Dermatology 2016;15(1):47-52

2016Positive (efficacy)PMID:26741381View source ↗

Hwang JS, Lee HY, Lim TY, Kim MY, Yoon TJ, Disruption of tyrosinase glycosylation by N-acetylglucosamine and its depigmenting effects in guinea pig skin and in human skin, Journal of Dermatological Science 2011;63(3):199-201

2011Mechanism onlyPMID:21723097View source ↗

Kimball AB, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL, Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial, British Journal of Dermatology 2010;162(2):435-41 — 10-week RCT (n=202) showed niacinamide + NAG reduced facial spots and hyperpigmentation beyond SPF 15 alone

2010Positive (efficacy)PMID:19845667View source ↗
NiacinamideStrong evidence10 citations

A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278444View source ↗

Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026

2026Positive (efficacy)PMID:41240206View source ↗

Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025

2025Positive (efficacy)PMID:39171587View source ↗
Panax GinsengStrong evidence5 citations

A staple in Hanbang (traditional Korean medicine) skincare. It's packed with antioxidants and ginsenosides that help firm the skin, boost circulation, and defend against environmental aging.

Jung SW et al., Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair, Annals of Dermatology 2025

2025Mechanism onlyPMID:39894668View source ↗

Kim H et al., The Beneficial Effect of Korean Red Ginseng Extract on Atopic Dermatitis Patients: An 8 Weeks Open, Noncomparative Clinical Study, Annals of Dermatology 2018

2018Positive (efficacy)PMID:29853744View source ↗

Park HM et al., A single-center, randomized, double-blind, placebo-controlled study on the efficacy and safety of enzyme-treated red ginseng powder complex (BG11001) for antiwrinkle and proelasticity in individuals with healthy skin, Journal of Ginseng Research 2016

2016Positive (efficacy)PMID:27616902View source ↗
PropolisModerate evidence6 citations

A bee-made resin that's antibacterial and anti-inflammatory. Calms breakouts and hydrates at the same time.

Chantadee T et al., In Situ Thai Apis mellifera Propolis Film as Potential Protective Phytopharmaceuticals Against UVB-Induced HaCaT Keratinocyte Damage, Pharmaceuticals (Basel) 2026

2026Mechanism onlyPMID:42198354View source ↗

Effect of propolis on wound healing in sacrococcygeal pilonidal disease: a randomized controlled clinical trial, 2021 — accelerated wound healing from week 1 with greater effect days 14-28 vs control

2021Positive (efficacy)PMID:34602433View source ↗

Martin BA et al., A New Approach to Atopic Dermatitis Control with Low-Concentration Propolis-Loaded Cold Cream, Pharmaceutics 2021;13(9):1346 — low-concentration propolis cold cream reduced atopic-dermatitis severity

2021Positive (efficacy)PMID:34575421View source ↗
Snow MushroomAnecdotal evidence4 citations

Often pitched as the gentler cousin of hyaluronic acid. It holds water in the skin, fades less quickly in dry air, and quietly buffers against UV oxidative stress.

Zhang Y et al., iTRAQ-Based Proteomic Profiling of Skin Aging Protective Effects of Tremella fuciformis-Derived Polysaccharides on D-Galactose-Induced Aging Mice, Molecules 2024

2024Mechanism onlyPMID:39519833View source ↗

Lin M et al., Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2, Photochemistry and Photobiology Sciences 2023;22(10) — topical TFPS treatment in chronic UV-irradiated mouse model reduced photoaging markers and protected skin cells from UVA-induced damage

2023Positive (efficacy)PMID:37458972View source ↗

Shen T et al., Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by up-regulating Nrf2/Keap1 pathways, Journal of Cosmetic Dermatology 2021

2021Mechanism onlyPMID:33686752View source ↗
Witch HazelAnecdotal evidence4 citations

A botanical astringent backed by real anti-inflammatory evidence. Extracts genuinely calm acne-related inflammation by blocking the same NF-κB pathway that redness-causing cytokines depend on. Honest caveat: most shelf-ready witch hazel toners are distilled water with trace tannin; look for "Hamamelis virginiana extract" rather than "hamamelis water" on the label if you want the active fraction.

Liu X, Hage TW, Chen LC, Wang EHC, Liao IC, Goldberg J, et al. Revealing the Therapeutic Potential: Investigating the Impact of a Novel Witch Hazel Formula on Anti-Inflammation and Antioxidation. Journal of Cosmetic Dermatology. 2025 Feb. — Clinical evaluation of a novel witch hazel formula demonstrating anti-inflammatory and antioxidant effects on skin.

2025Positive (efficacy)PMID:39575475View source ↗

Wojciak M, Pacuła W, Sowa I, Feldo M, Graczyk F, Załuski D. Hamamelis virginiana L. in Skin Care: A Review of Its Pharmacological Properties and Cosmetological Applications. Molecules. 2025 Jun 26;30(13):2744. — Narrative review of pharmacological properties and skin care applications of Hamamelis virginiana.

2025Positive (efficacy)PMID:40649262View source ↗

Piazza S, Martinelli G, Vrhovsek U, Masuero D, Fumagalli M, Magnavacca A, et al. Anti-Inflammatory and Anti-Acne Effects of Hamamelis virginiana Bark in Human Keratinocytes. Antioxidants. 2022;11(6):1119.

2022Mechanism onlyPMID:35740016View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

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