Shop Paula's Choice SKIN PERFECTING 8% AHA Gel Exfoliant with Glycolic Acid (3.3 oz)
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Paula's Choice

SKIN PERFECTING 8% AHA Gel Exfoliant with Glycolic Acid (3.3 oz)

~$16· 3.3 oz
Dark spotsRadianceDrynessRedness

Evidence behind the ingredients

Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Glycolic AcidStrong evidence6 citations

Exfoliates the surface of your skin to smooth rough texture and fade dullness. The strongest of the AHAs, so start slow.

Liu H et al., Topical agents for acne (covers AHA / fruit-acid arm), Cochrane Database of Systematic Reviews 2020;5:CD011368 — conclusion: clinical benefit is unclear

2020Meta-analysis — mixedPMID:32356369View source ↗

Sarkar R et al., Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic-Mandelic Acid, and Phytic Acid Combination Peels in Melasma, Dermatologic Surgery 2016;42(3):384-391 — 35% glycolic acid and salicylic-mandelic peels equally effective and safe for melasma in Indian skin

2016Positive — efficacyPMID:26859648View source ↗

Kubiak M et al., Evaluation of 70% glycolic peels versus 15% trichloroacetic peels for the treatment of photodamaged facial skin in aging women, Dermatologic Surgery 2014;40(8):883-891 — both peels improved photodamaged skin; glycolic acid showed faster hydration recovery

2014Positive — efficacyPMID:25068547View source ↗
ChamomileModerate evidence5 citations

The classic "tea-bag-on-puffy-eyes" botanical. Calms angry skin via the same anti-inflammatory pathways psoriasis drugs target, just gentler. Good for reactive or rosacea-prone complexions.

Essential Oil of Matricaria chamomilla Alleviates Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway, Clinical Cosmetic and Investigational Dermatology 2024

2024Mechanism onlyPMID:38222858View source ↗

Phytochemical, Technological, and Pharmacological Study on the Galenic Dry Extracts Prepared from German Chamomile Flowers (Romania), Plants 2024

2024Mechanism onlyPMID:38337883View source ↗

Comparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. (Germany), Frontiers in Immunology 2024

2024Mechanism onlyPMID:38720895View source ↗
Aloe VeraModerate evidence5 citations

Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

Tungkasamit T et al., Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial, European Journal of Oncology Nursing 2022;59:102164 — aloe vera reduced severity of moderate-to-severe radiation dermatitis

2022Positive — efficacyPMID:35767935View source ↗

Hekmatpou D et al., The effect of aloe vera clinical trials on prevention and healing of skin wound: a systematic review, Iranian Journal of Medical Sciences 2019;44(1):1-9

2019Meta-analysis — positivePMID:30666070View source ↗

Burusapat C et al., Topical Aloe Vera Gel for Accelerated Wound Healing of Split-Thickness Skin Graft Donor Sites: A Double-Blind, Randomized, Controlled Trial and Systematic Review, Plastic and Reconstructive Surgery 2018;142(1):217-226 — aloe vera gel shortened donor-site reepithelialization to 11.5 vs 13.7 days

2018Positive — efficacyPMID:29649056View source ↗
+3 more ingredients
Hyaluronic AcidStrong evidence7 citations

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis — positivePMID:36200921View source ↗

Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020

2020Mechanism onlyPMID:33911737View source ↗

An JH et al., Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin, Annals of Dermatology 2019;31(3):263-271 — cross-linked HA microneedle patches improved wrinkles on Korean skin with minimal discomfort

2019Positive — efficacyPMID:33911590View source ↗
PanthenolModerate evidence5 citations

Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.

Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline

2025Positive — efficacyPMID:40613435View source ↗

Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD

2022Meta-analysis — positivePMID:35887707View source ↗

Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser

2019Positive — efficacyPMID:30897983View source ↗
Sodium PCAModerate evidence4 citations

Replenishes one of the actual humectant molecules your own skin makes. Levels drop in eczema and with age, so topping it up genuinely helps dry, dehydrated, or atopic-prone skin feel less tight.

Novel design of pyrrolidonecarboxylic acid and sodium dilauramidoglutamide lysine complex for targeted drug delivery to human stratum corneum, International Journal of Pharmaceutics 2025

2025Mechanism onlyPMID:40187708View source ↗

Baldwin H, Del Rosso J, Going Beyond Ceramides in Moisturizers: The Role of Natural Moisturizing Factors, Journal of Drugs in Dermatology 2024 — review establishing PCA (pyrrolidone carboxylic acid) as a core skin natural moisturizing factor alongside amino acids, urea, lactate, and electrolytes; essential to barrier function and xerosis treatment

2024Mechanism onlyPMID:38834224View source ↗

Li L et al., Association Between Skin Acid Mantle, Natural Moisturizing Factors, and Antibacterial Activity Against S. aureus in the Stratum Corneum, Clinical Cosmetic and Investigational Dermatology 2023 — PCA and urocanic acid as NMF components contribute to skin antibacterial defense; 1-unit pH drop = 68.1% S. aureus cell death

2023Mechanism onlyPMID:37378303View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Retinol + glycolic acid is a classic barrier-buster. Use on different nights.

  • Tretinoin + glycolic acid causes significant barrier disruption. Never layer.

  • Adapalenemedium

    Adapalene + glycolic acid can over-exfoliate. Alternate nights.

  • AHA + BHA stacking risks over-exfoliation. Use a pre-formulated AHA/BHA product or alternate days.

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