Regeneration Booster
What it's good for
Key actives from our research database. Click any to read the full evidence dossier.
A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.
Good for: Anti-inflammatory, Hydrating
A fruit-derived AHA that exfoliates and antioxidizes. It shares the same basic mechanism as glycolic and lactic acid but is weaker gram-for-gram; in practice you'll see it doing dual duty (a little exfoliation plus pH stabilisation) in multi-acid toners and serums. When it appears low on an ingredient list, it's adjusting pH; higher up, it's contributing real exfoliation.
Good for: Exfoliating, Antioxidant
A naturally-occurring antioxidant your skin loses as you age. Topical CoQ10 restores some of what time depletes, supporting energy production in skin cells and softening wrinkle depth.
Good for: Antioxidant, Anti-aging
A silicone that sits on your skin as an invisible, non-greasy shield. Reduces water loss, protects against irritants (think soap, friction, incontinence), and is FDA-recognised as a skin protectant from 1-30%. The reason your favourite primer feels silky and your barrier cream actually works under makeup.
Good for: Barrier repair, Hydrating
A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.
Good for: Hydrating
A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.
Good for: Hydrating
An essential fatty acid your sebum runs short on if you're acne-prone, and topping it up topically literally shrinks clogged pores. Also rebuilds the lipid mortar between skin cells. Found concentrated in safflower, hemp, and rosehip oils.
Good for: Barrier repair, Anti-acne
Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.
Good for: Anti-aging
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Good for: Hydrating, Barrier repair
A rich, naturally occlusive plant butter from the African karite tree. Soothes dry, irritation-prone skin, refills the lipid barrier, and was well tolerated enough in randomized trials that most participants used it comfortably as a daily emollient.
Good for: Barrier repair, Hydrating, Anti-inflammatory
A workhorse antioxidant that defends your skin from daily oxidative damage. Pairs especially well with vitamin C, and it's in nearly every good moisturizer for a reason.
Good for: Antioxidant
Evidence behind the ingredients
Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.
Xu Z et al., Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel for the Treatment of Rosacea, Journal of Cosmetic Dermatology 2025;24(4):e70129 — RCT (n=82, 12 weeks): allantoin gel improved erythema and alleviated itching/burning vs traditional therapy
Tan C et al., The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes, International Journal of Cosmetic Science 2024;46(5):691-701 — in vitro: allantoin combination reduced UVB-induced PGE2, IL-1α, IL-6, IL-8, TNFα
Saucedo-Acuna RA et al. (Mexico), Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds, International Journal of Molecular Sciences 2023;24(8):7377 — allantoin-pectin hydrogel reduced wound healing time by ~71% with complete closure at day 15 in rat model
A fruit-derived AHA that exfoliates and antioxidizes. It shares the same basic mechanism as glycolic and lactic acid but is weaker gram-for-gram; in practice you'll see it doing dual duty (a little exfoliation plus pH stabilisation) in multi-acid toners and serums. When it appears low on an ingredient list, it's adjusting pH; higher up, it's contributing real exfoliation.
Tang SC, Yang JH. Dual Effects of Alpha-Hydroxy Acids on the Skin. Molecules. 2018;23(4):863.
Yamamoto Y, Uede K, Yonei N, Kishioka A, Ohtani T, Furukawa F. Effects of alpha-hydroxy acids on the human skin of Japanese subjects: the rationale for chemical peeling. Journal of Dermatology. 2006 Jan;33(1):16-22. — Clinical-mechanistic study in Japanese subjects demonstrating AHA (including citric acid class) keratolytic and epidermal renewal effects as rationale for chemical peeling.
Bernstein EF, Underhill CB, Lakkakorpi J, et al. Citric acid increases viable epidermal thickness and glycosaminoglycan content of sun-damaged skin. Dermatologic Surgery. 1997 Aug;23(8):689-694. — Mechanistic study showing topical citric acid increased viable epidermal thickness and dermal glycosaminoglycans in sun-damaged skin, similar to glycolic acid and retinoic acid.
A naturally-occurring antioxidant your skin loses as you age. Topical CoQ10 restores some of what time depletes, supporting energy production in skin cells and softening wrinkle depth.
Li S et al., Ginsenoside Nanoliposomes Deliver Ergothioneine and Coenzyme Q10 to Address Skin Aging via Mitochondrial Mechanisms, Colloids and Surfaces B: Biointerfaces 2026
Lain ET, Agrawal N, Ruvolo E, Weise JM, Callender VD, The Role of Coenzyme Q10 in Skin Aging and Opportunities for Topical Intervention: A Review, Journal of Clinical and Aesthetic Dermatology 2024;17(8):42-47
Ayunin Q, Miatmoko A, Soeratri W, Erawati T, Susanto J, Legowo D, Improving the anti-ageing activity of coenzyme Q10 through protransfersome-loaded emulgel, Scientific Reports 2022;12(1):906 — topical CoQ10 protransfersomal emulgel increased collagen density and fibroblast count in UV-aged mouse skin
+−8 more ingredients
A silicone that sits on your skin as an invisible, non-greasy shield. Reduces water loss, protects against irritants (think soap, friction, incontinence), and is FDA-recognised as a skin protectant from 1-30%. The reason your favourite primer feels silky and your barrier cream actually works under makeup.
Beeckman D, Verhaeghe S, Defloor T, et al. A 3-in-1 perineal care washcloth impregnated with dimethicone 3% versus water and pH neutral soap to prevent and treat incontinence-associated dermatitis: a randomized, controlled clinical trial. J Wound Ostomy Continence Nurs. 2011;38(6):627-634.
Saary J, Qureshi R, Palda V, et al. A systematic review of contact dermatitis treatment and prevention. J Am Acad Dermatol. 2005;53(5):845-855. (Barrier creams containing dimethicone prevent irritant contact dermatitis.)
FDA OTC Final Monograph, 21 CFR Part 347 — Skin Protectant Drug Products for Over-the-Counter Human Use; dimethicone listed at section 347.10 as a Category I active ingredient at 1-30%.
A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.
Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection
Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin
Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration
A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.
Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.
Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging
Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020
An essential fatty acid your sebum runs short on if you're acne-prone, and topping it up topically literally shrinks clogged pores. Also rebuilds the lipid mortar between skin cells. Found concentrated in safflower, hemp, and rosehip oils.
Lin TK, Zhong L, Santiago JL. Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. Int J Mol Sci. 2017;19(1):70. — reviews linoleic-acid-rich oils in barrier repair.
Liu M et al., Topical application of a linoleic acid-ceramide containing moisturizer exhibit therapeutic and preventive benefits for psoriasis vulgaris: a randomized controlled trial, Dermatol Ther 2015;28(6):373-82 — RCT linoleic-acid/ceramide cream improved barrier
Letawe C, Boone M, Pierard GE. Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones. Clin Exp Dermatol. 1998;23(2):56-58.
Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.
Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles
Aruan RR et al., Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet, Journal of Clinical and Aesthetic Dermatology 2023;16(2):37-43 — RCT of topical palmitoyl pentapeptide-4 (Matrixyl) for periorbital wrinkles
Imhof L, Leuthard D, Topical Over-the-Counter Antiaging Agents: An Update and Systematic Review, Dermatology 2021;237(2):217-229 — SR covering topical antiaging peptides
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline
Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD
Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser
A rich, naturally occlusive plant butter from the African karite tree. Soothes dry, irritation-prone skin, refills the lipid barrier, and was well tolerated enough in randomized trials that most participants used it comfortably as a daily emollient.
O'Connor RJ et al., Clinical Evaluation of a Diaper Containing a Shea Butter-Based Emollient and Impact on Diapered Skin Erythema, Pediatr Dermatol 2025;42(3):532-538 — RCT n=271 infants, shea-butter diaper reduced dermatitis
Burnett CL, Bergfeld WF, Belsito DV, et al. Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel Final Report.
Verallo-Rowell VM, Katalbas SS, Pangasinan JP. Natural (Mineral, Vegetable, Coconut, Essential) Oils and Contact Dermatitis. Curr Allergy Asthma Rep. 2016;16(7):51. — discussing shea butter unsaponifiable fraction NF-kB inhibition and dermatologic use.
A workhorse antioxidant that defends your skin from daily oxidative damage. Pairs especially well with vitamin C, and it's in nearly every good moisturizer for a reason.
Neves JR et al., Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs, Journal of Cosmetic Dermatology 2022;21(10):4462-4469 — tocopherol-containing antioxidant serum reduced pollution-induced damage and improved aging signs
Warshaw EM et al., Patch Testing With Tocopherol and Tocopherol Acetate: The North American Contact Dermatitis Group Experience, 2001 to 2016, Dermatitis 2021;32(5):308-318 — 15-year NACDG data: positive patch-test reactions to tocopherol rare given widespread cosmetic use
Lin FH et al., Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin, Journal of Investigative Dermatology 2005;125(4):826-832 — ferulic acid + vit C + vit E combo doubled photoprotection vs C+E alone (cross-listed; same paper cited for Ferulic Acid and Vit C)
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.
Similar comparisons
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