Water Drench Hyaluronic Cloud Hydra-Gel Eye Patches
Tracked ingredients
Key actives from our research database. Click any to read the full evidence dossier.
Evidence behind the ingredients
Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.
Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection
Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration
Fluhr JW et al., Glycerol and the skin: holistic approach to its origin and functions, British Journal of Dermatology 2008;159(1):23-34 — improves xerosis and barrier function
A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.
Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging
Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020
An JH et al., Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin, Annals of Dermatology 2019;31(3):263-271 — cross-linked HA microneedle patches improved wrinkles on Korean skin with minimal discomfort
The protein your skin loses with age, broken down small enough to absorb. Multiple meta-analyses of RCTs show measurable wins in wrinkles, elasticity, and hydration after ~12 weeks. Most evidence is oral, but topical helps surface hydration too.
Pu SY et al., Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis, Nutrients 2023;15(9):2080 — 26 RCTs / 1,721 patients: hydrolyzed collagen significantly improved skin hydration and elasticity vs placebo across multiple collagen sources
de Miranda RB, Weimer P, Rossi RC, Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis, International Journal of Dermatology 2021 — 19 RCTs / 1,125 participants: 90-day oral hydrolyzed collagen significantly reduced wrinkles and improved skin elasticity and hydration vs placebo
Evans M et al., A randomized triple-blind placebo-controlled parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity, Journal of Cosmetic Dermatology 2021;20(3):825-834 — 12-week RCT: ~35% reduction in wrinkle scores and improved elasticity vs placebo
+−8 more ingredients
Tightens and brightens the under-eye area, reducing the look of puffiness by constricting tiny blood vessels. Best deployed in eye creams.
Elias M et al., Caffeine in Skincare: Its Role in Skin Cancer, Sun Protection, and Cosmetics, Indian Journal of Dermatology 2023;68(5):546-550 — evidence for topical caffeine's photoprotective, antioxidant, and anti-cellulite roles
Gherardini J et al. (Germany), Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine, International Journal of Cosmetic Science 2019;41(2):164-182 — topical caffeine reduced UV-induced hair follicle cytotoxicity and premature catagen entry in ex vivo human scalp
Byun SY et al., Efficacy of Slimming Cream Containing 3.5% Water-Soluble Caffeine and Xanthenes for the Treatment of Cellulite, Annals of Dermatology 2015;27(3):243-249 — 3.5% caffeine slimming cream improved visual cellulite scores 19.8% with measurable circumference reductions over 6 weeks
Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.
Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control
Kawamoto A et al., Chain length of covalently bound ceramides correlates with skin barrier function in healthy subjects, Journal of Dermatological Science 2023;110(1):35-38 — clinical study: SC ceramide chain length directly correlates with barrier function; longer-chain ceramides are the functionally relevant species
Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults
A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.
Xu Z et al., Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel for the Treatment of Rosacea, Journal of Cosmetic Dermatology 2025;24(4):e70129 — RCT (n=82, 12 weeks): allantoin gel improved erythema and alleviated itching/burning vs traditional therapy
Tan C et al., The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes, International Journal of Cosmetic Science 2024;46(5):691-701 — in vitro: allantoin combination reduced UVB-induced PGE2, IL-1α, IL-6, IL-8, TNFα
Saucedo-Acuna RA et al. (Mexico), Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds, International Journal of Molecular Sciences 2023;24(8):7377 — allantoin-pectin hydrogel reduced wound healing time by ~71% with complete closure at day 15 in rat model
A workhorse antioxidant that defends your skin from daily oxidative damage. Pairs especially well with vitamin C, and it's in nearly every good moisturizer for a reason.
Neves JR et al., Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs, Journal of Cosmetic Dermatology 2022;21(10):4462-4469 — tocopherol-containing antioxidant serum reduced pollution-induced damage and improved aging signs
Warshaw EM et al., Patch Testing With Tocopherol and Tocopherol Acetate: The North American Contact Dermatitis Group Experience, 2001 to 2016, Dermatitis 2021;32(5):308-318 — 15-year NACDG data: positive patch-test reactions to tocopherol rare given widespread cosmetic use
Lin FH et al., Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin, Journal of Investigative Dermatology 2005;125(4):826-832 — ferulic acid + vit C + vit E combo doubled photoprotection vs C+E alone (cross-listed; same paper cited for Ferulic Acid and Vit C)
A rich, naturally occlusive plant butter from the African karite tree. Calms eczema-prone skin, refills the lipid barrier, and (in randomized trials) is acceptable and effective enough that three quarters of pediatric AD patients use it as a steroid-sparing emollient.
Burnett CL, Bergfeld WF, Belsito DV, et al. Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel Final Report.
Verallo-Rowell VM, Katalbas SS, Pangasinan JP. Natural (Mineral, Vegetable, Coconut, Essential) Oils and Contact Dermatitis. Curr Allergy Asthma Rep. 2016;16(7):51. — discussing shea butter unsaponifiable fraction NF-kB inhibition and dermatologic use.
Hon KL, Tsang YC, Pong NH, et al. Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for eczema. Hong Kong Med J. 2015;21(5):417-425.
A gentle Asian-skincare brightener derived from licorice root. Fades dark spots and calms redness, and it's a pregnancy-safe alternative to stronger fade ingredients.
Glabridin Inhibits Melanogenesis and Melanin Transfer via Wnt/beta-Catenin Pathway and Rho Family GTPase-Mediated Dendritic Formation Suppression, Pharmaceuticals (Basel) 2026;19(3) — glabridin (the licorice-root active) suppressed melanin synthesis and keratinocyte melanin transfer in vitro via Wnt/beta-Catenin and Rho-GTPase dendrite suppression
Liu Y et al., Glycyrrhiza glabra extract as a skin-whitening agent: Identification of active components and CRTC1/MITF pathway-inhibition mechanism, Journal of Ethnopharmacology 2025;349:119948 — identifies glabridin as the principal active and maps skin-whitening mechanism via CREB/CRTC1/MITF suppression
Wang JY et al., Preparation of compound liquorice microemulsion gel and its pharmacodynamics evaluation, Zhongguo Zhong Yao Za Zhi (China Journal of Chinese Materia Medica) 2020;45(21):5193-5199 — compound licorice (Glycyrrhiza) microemulsion gel significantly reduced ear swelling and inflammatory infiltration in chronic eczema mouse model
A "natural skin lightener" with actual clinical-trial backing for melasma. A placebo-controlled study showed real MASI improvement. Sits well alongside vitamin C, alpha-arbutin, or niacinamide in a brightening stack.
Zhang L et al., Moraceae Plants with Tyrosinase Inhibitory Activity: A Review, Mini Reviews in Medicinal Chemistry 2017;17(13):1148-1157 — Morus alba and related Moraceae compounds demonstrate enzymatic tyrosinase inhibition and clinical whitening effects competitive with available depigmenting agents
Alvin G et al., A comparative study of the safety and efficacy of 75% mulberry (Morus alba) extract oil versus placebo as a topical treatment for melasma, Journal of Drugs in Dermatology 2011;10(9):1025-1031 — RCT: topical 75% mulberry extract significantly reduced MASI and Mexameter readings and improved QoL vs placebo with minimal adverse events
Calms irritation and adds light hydration. The classic for sunburned or reactive skin.
Tungkasamit T et al., Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial, European Journal of Oncology Nursing 2022;59:102164 — aloe vera reduced severity of moderate-to-severe radiation dermatitis
Hekmatpou D et al., The effect of aloe vera clinical trials on prevention and healing of skin wound: a systematic review, Iranian Journal of Medical Sciences 2019;44(1):1-9
Burusapat C et al., Topical Aloe Vera Gel for Accelerated Wound Healing of Split-Thickness Skin Graft Donor Sites: A Double-Blind, Randomized, Controlled Trial and Systematic Review, Plastic and Reconstructive Surgery 2018;142(1):217-226 — aloe vera gel shortened donor-site reepithelialization to 11.5 vs 13.7 days
Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.
Similar comparisons
Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.